经皮睾酮疗法对围绝经期和绝经后妇女情绪和认知症状的影响:一项试点研究。

IF 3.2 3区 医学 Q2 PSYCHIATRY
Sarah Glynne, Aini Kamal, Ahmed M Kamel, Dan Reisel, Louise Newson
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引用次数: 0

摘要

目的:本研究旨在评估睾酮疗法对围绝经期和绝经后妇女情绪和认知症状的影响:方法:在英国一家更年期专科诊所进行的一项回顾性队列研究。510名使用激素替代疗法(HRT)的女性持续存在性欲低下、认知和负面情绪症状,她们接受了为期4个月的睾酮霜或凝胶治疗。在开始治疗的基线和4个月后,使用改良版的格林更年期量表来测量自我报告的症状频率和严重程度:结果:在整个研究期间,所有九种认知症状和情绪症状都有明显改善。情绪改善程度高于认知改善程度(47% 的女性报告情绪改善,39% 的女性报告认知改善;平均症状评分分别下降 34% 和 22%)。在性欲方面,52%的女性表示有所改善;平均症状评分下降了33%:结论:持续 4 个月的透皮睾酮疗法可显著改善情绪和认知能力。需要进一步开展研究,包括随机临床试验,以确定睾酮治疗更年期认知和心理症状的长期疗效和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of transdermal testosterone therapy on mood and cognitive symptoms in peri- and postmenopausal women: a pilot study.

Purpose: The purpose of this study was to assess the impact of testosterone therapy on mood and cognitive symptoms in perimenopausal and postmenopausal women.

Methods: A retrospective cohort study undertaken in a UK specialist menopause clinic. 510 women using hormone replacement therapy (HRT) with persistent low libido, cognitive and negative mood symptoms were treated with testosterone cream or gel for 4 months. A modified version of the Greene Climacteric Scale was used to measure self-reported symptom frequency and severity at baseline and 4 months after initiating treatment.

Results: All nine cognitive and mood symptoms significantly improved across the study period. Mood improved more than cognition (47% of women reported an improvement in mood vs. 39% reported an improvement in cognition; 34% vs. 22% decrease in mean symptom scores, respectively). Regarding libido, 52% of women reported an improvement; mean symptom score decreased by 33%.

Conclusion: Transdermal testosterone therapy for 4 months was associated with significant improvements in mood and cognition. Further research including randomised clinical trials are needed to establish the long-term efficacy and safety of testosterone for the treatment of menopausal cognitive and psychological symptoms.

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来源期刊
Archives of Women's Mental Health
Archives of Women's Mental Health 医学-精神病学
CiteScore
8.00
自引率
4.40%
发文量
83
审稿时长
6-12 weeks
期刊介绍: Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.
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