Boyu Liu, Ran Wei, Hongbo Zhu, Xuelu Zhao, Guang Wang
{"title":"神经肌肉电刺激与布洛芬相结合，减轻股骨头坏死患者的疼痛。","authors":"Boyu Liu, Ran Wei, Hongbo Zhu, Xuelu Zhao, Guang Wang","doi":"10.62347/NEOQ3253","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The combinative effects of neuromuscular electrical stimulation and ibuprofen on pain in patients with femoral head necrosis were discussed and analyzed.</p><p><strong>Method: </strong>This retrospective study analyzed data of 60 patients with femoral head necrosis hospitalized during Oct. 2020 to Oct. 2021. According to different treatment methods, the patients were divided into an observation group and a control group (30 cases in each group). The control group took oral ibuprofen sustained-release capsules, and the observation group was treated with neuromuscular electrical stimulation in addition to ibuprofen. Both groups received a 4-week treatment course. The therapeutic efficacy, Harris scale scores, Visual Analogue Scale (VAS) score, MRI hip imaging stage, SF-36 scale score, serum plasminogen activator inhibitor 1 (PAI-1), leptin and osteopontin levels before and after treatment were compared between the two groups.</p><p><strong>Results: </strong>After treatment, the overall response rate in the observation group was higher than that in control group (<i>P<0.05</i>). The post-treatment scores of Harris scale were higher in both groups than those pre-treatment (<i>P<0.05</i>), and were higher in the observation group than in the control group (<i>P<0.05</i>). The VAS scores were decreased in both groups (<i>P<0.05</i>), and the decrease was more significant in the observation group than in the control group (<i>P<0.05</i>). After treatment, there were more patients with 0-I MRI hip imaging stage in the two groups than before treatment (<i>P<0.05</i>), and more in the observation group than in the control group (<i>P<0.05</i>). The SF-36 scores in both groups were increased (<i>P<0.05</i>), and the increase was more significant in the observation group than in the control group (<i>P<0.05</i>). The serum levels of PAI-1, leptin and osteopontin were decreased in both groups (<i>P<0.05</i>), and the decreases were more significant in the observation group than in the control group (<i>P<0.05</i>).</p><p><strong>Conclusion: </strong>The combinative treatment of neuromuscular electrical stimulation and ibuprofen has a significant effect on patients with femoral head necrosis. The treatment can remarkably reduce patients' pain, improve their hip function and quality of life, and decrease the PAI-1, leptin and osteopontin levels.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384367/pdf/","citationCount":"0","resultStr":"{\"title\":\"Combination of neuromuscular electrical stimulation and ibuprofen to reduce pain in femoral head necrosis.\",\"authors\":\"Boyu Liu, Ran Wei, Hongbo Zhu, Xuelu Zhao, Guang Wang\",\"doi\":\"10.62347/NEOQ3253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The combinative effects of neuromuscular electrical stimulation and ibuprofen on pain in patients with femoral head necrosis were discussed and analyzed.</p><p><strong>Method: </strong>This retrospective study analyzed data of 60 patients with femoral head necrosis hospitalized during Oct. 2020 to Oct. 2021. According to different treatment methods, the patients were divided into an observation group and a control group (30 cases in each group). The control group took oral ibuprofen sustained-release capsules, and the observation group was treated with neuromuscular electrical stimulation in addition to ibuprofen. Both groups received a 4-week treatment course. The therapeutic efficacy, Harris scale scores, Visual Analogue Scale (VAS) score, MRI hip imaging stage, SF-36 scale score, serum plasminogen activator inhibitor 1 (PAI-1), leptin and osteopontin levels before and after treatment were compared between the two groups.</p><p><strong>Results: </strong>After treatment, the overall response rate in the observation group was higher than that in control group (<i>P<0.05</i>). The post-treatment scores of Harris scale were higher in both groups than those pre-treatment (<i>P<0.05</i>), and were higher in the observation group than in the control group (<i>P<0.05</i>). The VAS scores were decreased in both groups (<i>P<0.05</i>), and the decrease was more significant in the observation group than in the control group (<i>P<0.05</i>). After treatment, there were more patients with 0-I MRI hip imaging stage in the two groups than before treatment (<i>P<0.05</i>), and more in the observation group than in the control group (<i>P<0.05</i>). The SF-36 scores in both groups were increased (<i>P<0.05</i>), and the increase was more significant in the observation group than in the control group (<i>P<0.05</i>). The serum levels of PAI-1, leptin and osteopontin were decreased in both groups (<i>P<0.05</i>), and the decreases were more significant in the observation group than in the control group (<i>P<0.05</i>).</p><p><strong>Conclusion: </strong>The combinative treatment of neuromuscular electrical stimulation and ibuprofen has a significant effect on patients with femoral head necrosis. The treatment can remarkably reduce patients' pain, improve their hip function and quality of life, and decrease the PAI-1, leptin and osteopontin levels.</p>\",\"PeriodicalId\":7731,\"journal\":{\"name\":\"American journal of translational research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384367/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of translational research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/NEOQ3253\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/NEOQ3253","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Combination of neuromuscular electrical stimulation and ibuprofen to reduce pain in femoral head necrosis.
Objective: The combinative effects of neuromuscular electrical stimulation and ibuprofen on pain in patients with femoral head necrosis were discussed and analyzed.
Method: This retrospective study analyzed data of 60 patients with femoral head necrosis hospitalized during Oct. 2020 to Oct. 2021. According to different treatment methods, the patients were divided into an observation group and a control group (30 cases in each group). The control group took oral ibuprofen sustained-release capsules, and the observation group was treated with neuromuscular electrical stimulation in addition to ibuprofen. Both groups received a 4-week treatment course. The therapeutic efficacy, Harris scale scores, Visual Analogue Scale (VAS) score, MRI hip imaging stage, SF-36 scale score, serum plasminogen activator inhibitor 1 (PAI-1), leptin and osteopontin levels before and after treatment were compared between the two groups.
Results: After treatment, the overall response rate in the observation group was higher than that in control group (P<0.05). The post-treatment scores of Harris scale were higher in both groups than those pre-treatment (P<0.05), and were higher in the observation group than in the control group (P<0.05). The VAS scores were decreased in both groups (P<0.05), and the decrease was more significant in the observation group than in the control group (P<0.05). After treatment, there were more patients with 0-I MRI hip imaging stage in the two groups than before treatment (P<0.05), and more in the observation group than in the control group (P<0.05). The SF-36 scores in both groups were increased (P<0.05), and the increase was more significant in the observation group than in the control group (P<0.05). The serum levels of PAI-1, leptin and osteopontin were decreased in both groups (P<0.05), and the decreases were more significant in the observation group than in the control group (P<0.05).
Conclusion: The combinative treatment of neuromuscular electrical stimulation and ibuprofen has a significant effect on patients with femoral head necrosis. The treatment can remarkably reduce patients' pain, improve their hip function and quality of life, and decrease the PAI-1, leptin and osteopontin levels.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
