Cathy J. Reback, Demetria Cain, Joshua A. Rusow, David Benkeser, Lindsey Schader, Bevin A. Gwiazdowski, Simone J. Skeen, Marissa Hannah, Marvin Belzer, Marne Castillo, Kenneth H. Mayer, Mary E. Paul, Jonathan Hill-Rorie, Nathan Dorcey Johnson, Julie McAvoy-Banerjea, Travis Sanchez, Lisa B. Hightow-Weidman, Patrick S. Sullivan, Keith J. Horvath
{"title":"基于技术的干预措施，采用阶梯式护理方法，减少变性和性别扩展青年及年轻成年人的性风险行为，提高 PrEP 的启动率。","authors":"Cathy J. Reback, Demetria Cain, Joshua A. Rusow, David Benkeser, Lindsey Schader, Bevin A. Gwiazdowski, Simone J. Skeen, Marissa Hannah, Marvin Belzer, Marne Castillo, Kenneth H. Mayer, Mary E. Paul, Jonathan Hill-Rorie, Nathan Dorcey Johnson, Julie McAvoy-Banerjea, Travis Sanchez, Lisa B. Hightow-Weidman, Patrick S. Sullivan, Keith J. Horvath","doi":"10.1007/s10461-024-04513-w","DOIUrl":null,"url":null,"abstract":"<div><p><i>TechStep</i> was a technology-based trial, with a stepped care approach, to reduce sexual risks and increase PrEP uptake among transgender and gender expansive youth and young adults (15–24 years old). From October 2019 to September 2021, 254 participants were randomized into: 1) <i>Text</i> (n = 82), or 2) <i>Webapp</i> (n = 87), or 3) <i>Control</i> (n = 85). At the 3-month follow-up assessment, those randomized to <i>Text</i> and <i>Webapp</i> and did not demonstrate improvement on primary outcomes were re-randomized to receive virtual eCoaching (<i>Text</i> + or <i>Webapp</i> +), or to remain in their initial condition without eCoaching. Results showed no effect on condomless encounters at 6-month, the primary endpoint, when comparing the <i>Webapp</i> + (0.33 decrease; 95%CI: -0.01, 0.67, p-value = 0.057) or the <i>Text</i> + (0.27 decrease; 95%CI: -0.13, 0.68, p-value = 0.181) conditions to the <i>Control</i> condition. However, in secondary analyses, condomless encounters were significantly reduced for <i>Text</i> compared to <i>Control</i>. The rate of PrEP uptake was low for all study arms.</p><p><b>Trial registration</b>: Clinical Trials # NCT04000724 (registered June 26, 2019).</p></div>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":"28 12","pages":"3956 - 3969"},"PeriodicalIF":2.7000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Technology-Based Interventions, with a Stepped Care Approach, for Reducing Sexual Risk Behaviors and Increasing PrEP Initiation Among Transgender and Gender Expansive Youth and Young Adults\",\"authors\":\"Cathy J. Reback, Demetria Cain, Joshua A. Rusow, David Benkeser, Lindsey Schader, Bevin A. Gwiazdowski, Simone J. Skeen, Marissa Hannah, Marvin Belzer, Marne Castillo, Kenneth H. Mayer, Mary E. Paul, Jonathan Hill-Rorie, Nathan Dorcey Johnson, Julie McAvoy-Banerjea, Travis Sanchez, Lisa B. Hightow-Weidman, Patrick S. Sullivan, Keith J. Horvath\",\"doi\":\"10.1007/s10461-024-04513-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><i>TechStep</i> was a technology-based trial, with a stepped care approach, to reduce sexual risks and increase PrEP uptake among transgender and gender expansive youth and young adults (15–24 years old). From October 2019 to September 2021, 254 participants were randomized into: 1) <i>Text</i> (n = 82), or 2) <i>Webapp</i> (n = 87), or 3) <i>Control</i> (n = 85). At the 3-month follow-up assessment, those randomized to <i>Text</i> and <i>Webapp</i> and did not demonstrate improvement on primary outcomes were re-randomized to receive virtual eCoaching (<i>Text</i> + or <i>Webapp</i> +), or to remain in their initial condition without eCoaching. Results showed no effect on condomless encounters at 6-month, the primary endpoint, when comparing the <i>Webapp</i> + (0.33 decrease; 95%CI: -0.01, 0.67, p-value = 0.057) or the <i>Text</i> + (0.27 decrease; 95%CI: -0.13, 0.68, p-value = 0.181) conditions to the <i>Control</i> condition. However, in secondary analyses, condomless encounters were significantly reduced for <i>Text</i> compared to <i>Control</i>. The rate of PrEP uptake was low for all study arms.</p><p><b>Trial registration</b>: Clinical Trials # NCT04000724 (registered June 26, 2019).</p></div>\",\"PeriodicalId\":7543,\"journal\":{\"name\":\"AIDS and Behavior\",\"volume\":\"28 12\",\"pages\":\"3956 - 3969\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS and Behavior\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10461-024-04513-w\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS and Behavior","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s10461-024-04513-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Technology-Based Interventions, with a Stepped Care Approach, for Reducing Sexual Risk Behaviors and Increasing PrEP Initiation Among Transgender and Gender Expansive Youth and Young Adults
TechStep was a technology-based trial, with a stepped care approach, to reduce sexual risks and increase PrEP uptake among transgender and gender expansive youth and young adults (15–24 years old). From October 2019 to September 2021, 254 participants were randomized into: 1) Text (n = 82), or 2) Webapp (n = 87), or 3) Control (n = 85). At the 3-month follow-up assessment, those randomized to Text and Webapp and did not demonstrate improvement on primary outcomes were re-randomized to receive virtual eCoaching (Text + or Webapp +), or to remain in their initial condition without eCoaching. Results showed no effect on condomless encounters at 6-month, the primary endpoint, when comparing the Webapp + (0.33 decrease; 95%CI: -0.01, 0.67, p-value = 0.057) or the Text + (0.27 decrease; 95%CI: -0.13, 0.68, p-value = 0.181) conditions to the Control condition. However, in secondary analyses, condomless encounters were significantly reduced for Text compared to Control. The rate of PrEP uptake was low for all study arms.
Trial registration: Clinical Trials # NCT04000724 (registered June 26, 2019).
期刊介绍：
AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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