监测无定形非洛地平的等温结晶和时温转变：时域核磁共振法。

IF 3.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

AAPS PharmSciTech Pub Date : 2024-09-19 DOI:10.1208/s12249-024-02919-2

A. Pajzderska, M. A. Gonzalez, M. Jarek, J. Wąsicki

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引用次数: 0

摘要

采用时域核磁共振（NMR）方法研究了非洛地平在无定形块状样品和研磨样品中的等温结晶过程。获得的感应时间和结晶时间被用于构建高于和低于玻璃化转变温度（Tg）的时间-温度-转变（TTT）图。此外，还比较了结晶和无定形非洛地平在不同温度下的动态变化。分子动力学模拟也用于探索这两种体系的氢键相互作用和动态特性。

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Monitoring of Isothermal Crystallization and Time–Temperature Transformation of Amorphous Felodipine: The Time-Domain Nuclear Magnetic Resonance Method

The isothermal crystallization process of felodipine has been investigated using the time-domain Nuclear Magnetic Resonance (NMR) method for amorphous bulk and ground samples. The obtained induction and crystallization times were then used to construct the time–temperature-transformation (TTT) diagram, both above and below the glass transition temperature (T_g). The Nose temperature was found equal to 363 K. Furthermore, the dynamics of crystalline and amorphous felodipine were compared across varying temperatures. Molecular dynamics simulations were also employed to explore the hydrogen-bond interactions and dynamic properties of both systems.

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来源期刊

AAPS PharmSciTech 医学-药学

CiteScore

6.80

自引率

3.00%

发文量

264

审稿时长

2.4 months

期刊介绍： AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.