揭示骨关节炎关节中巨噬细胞的动态变化：从炎症到治疗策略。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-09-19 DOI:10.1016/j.drudis.2024.104187

Nicolas Gaigeard , Anaïs Cardon , Benoit Le Goff , Jérôme Guicheux , Marie-Astrid Boutet

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引用次数: 0

摘要

骨关节炎（OA）是一种无法治愈、令人痛苦和衰弱的关节疾病，影响着全球 5 亿多人。OA 关节组织被各种免疫细胞浸润，尤其是巨噬细胞，它们能够诱发或延续炎症。值得注意的是，滑膜炎及其巨噬细胞成分是开发治疗方法的一个目标。在这篇综述中，我们将介绍在了解 OA 关节中巨噬细胞的起源、表型和功能的异质性以及目前的对症疗法对这些细胞的影响方面取得的最新进展。然后，我们将重点介绍抗细胞因子/凝血因子、纳米和微药物递送的治疗潜力，以及调节 OA 中巨噬细胞功能的未来策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unveiling the macrophage dynamics in osteoarthritic joints: From inflammation to therapeutic strategies

Osteoarthritis (OA) is an incurable, painful, and debilitating joint disease affecting over 500 million people worldwide. The OA joint tissues are infiltrated by various immune cells, particularly macrophages, which are able to induce or perpetuate inflammation. Notably, synovitis and its macrophage component represent a target of interest for developing treatments. In this review, we describe the latest advances in understanding the heterogeneity of macrophage origins, phenotypes, and functions in the OA joint and the effect of current symptomatic therapies on these cells. We then highlight the therapeutic potential of anticytokines/chemokines, nano- and microdrug delivery, and future strategies to modulate macrophage functions in OA.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.