我们到了吗？逐个细胞探索星形胶质细胞的异质性

IF 5.4 2区医学 Q1 NEUROSCIENCES

Glia Pub Date : 2024-09-23 DOI:10.1002/glia.24621

Michael R O'Dea, Philip Hasel

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引用次数: 0

摘要

星形胶质细胞是大脑和脊髓中非常丰富的一种细胞类型。与神经元一样，星形胶质细胞在分子和功能上各不相同，可以发挥专门的作用。基于测序的单细胞检测技术的最新进展推动了omics数据的爆炸式增长，这些数据描述了健康、衰老、受伤和患病中枢神经系统中星形胶质细胞的特征。在这篇综述中，我们将讨论最近的一些研究，这些研究进一步加深了我们对星形胶质细胞生物学和异质性的理解，还将讨论基于测序的单细胞和空间基因组学方法的局限性和挑战及其未来的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Are we there yet? Exploring astrocyte heterogeneity one cell at a time.

Astrocytes are a highly abundant cell type in the brain and spinal cord. Like neurons, astrocytes can be molecularly and functionally distinct to fulfill specialized roles. Recent technical advances in sequencing-based single cell assays have driven an explosion of omics data characterizing astrocytes in the healthy, aged, injured, and diseased central nervous system. In this review, we will discuss recent studies which have furthered our understanding of astrocyte biology and heterogeneity, as well as discuss the limitations and challenges of sequencing-based single cell and spatial genomics methods and their potential future utility.

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来源期刊

Glia 医学-神经科学

CiteScore

13.10

自引率

4.80%

发文量

162

审稿时长

3-8 weeks

期刊介绍： GLIA is a peer-reviewed journal, which publishes articles dealing with all aspects of glial structure and function. This includes all aspects of glial cell biology in health and disease.