铜催化吲哚的有氧交叉脱氢偶联合成 2,3'-双吲哚。

IF 3.3 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Xinxiang Huang, Yingying Yang, Qiping He, Chang Liu, Mingquan Yuan, Yi Jin
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引用次数: 0

摘要

具有 C-C 连接的 2,3'-双吲哚在药物化学中备受关注,但其合成过程复杂,步骤繁多。值得注意的是,非定向杂芳烃的直接 C-H/C-H 交叉偶联仍然具有挑战性,通常需要贵金属和氧化剂来提高偶联效率。在此,我们提出了一种铜催化的 C-H/C-H 交叉偶联方法,在温和的条件下通过分子氧促进无定向基团的 N-取代吲哚的偶联。该方法显示出合理的官能团兼容性,并能以中等至良好的产率一锅获得多种 2,3'-双吲哚衍生物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Copper-Catalyzed Aerobic Cross-Dehydrogenation Coupling of Indoles for Synthesis of 2,3′-Bisindoles

Copper-Catalyzed Aerobic Cross-Dehydrogenation Coupling of Indoles for Synthesis of 2,3′-Bisindoles

2,3’-Bisindoles with C−C linkages have attracted interest in medicinal chemistry, yet their synthesis is intricate with many steps. Notably, direct C−H/C−H cross-coupling of non-directed heteroaromatics remains challenging, often requiring precious metals and oxidants to enhance coupling efficiency. Herein, we present a copper-catalyzed C−H/C−H cross-coupling method for N-substituted indoles without directing groups, facilitated by molecular oxygen under gentle conditions. It showed reasonable functional group compatibility and provided one-pot access to a variety of 2,3′-bisindoles derivatives in moderate to good yields.

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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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