2'-Fucosyllactose 通过调节肠道微生物-T 细胞轴减轻与衰老相关的代谢紊乱。

IF 8 1区 医学 Q1 CELL BIOLOGY
Aging Cell Pub Date : 2024-09-20 DOI:10.1111/acel.14343
Ang Li, Ruixin Kou, Ruishan Wang, Jin Wang, Bowei Zhang, Jingmin Liu, Yaozhong Hu, Shuo Wang
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引用次数: 0

摘要

与衰老相关的代谢紊乱严重影响了中老年人的寿命,这可能是由于适应性免疫和肠道微生物谱发生了紊乱。膳食干预为维持代谢健康提供了一种有前景的策略。本研究旨在探讨 2'-flucosyllactose (2'-FL)对衰老引起的代谢功能障碍的改善作用及其潜在机制。结果发现,2'-FL 能明显缓解与衰老有关的代谢紊乱,包括体重增加、脂质沉积、血脂异常、葡萄糖不耐受、全身炎症和肝脏代谢异常。流式细胞术分析表明,老年小鼠的T细胞毒性(Tc)、T辅助细胞(Th)和调节性T细胞(Treg)显著减少,Th17细胞显著增加,而2'-FL缓解了衰老引起的Th和Th17亚型的比例变化。衰老肠道微生态的特点是 Th17/Treg 比率升高、肠道屏障功能受损、肠道细菌多样性降低、有益菌属(包括舌状乳杆菌、 Colidextribacter、 Mucispirillum 和 Lachnoclostridium)数量减少,而有害菌(包括 Turicibacter 和 Desulfovibrio)数量增加。这些发现突出表明,2'-FL 是一种理想的膳食益生元,可通过调节适应性免疫系统和肠道微生物谱来改善与衰老相关的代谢紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
2'-Fucosyllactose attenuates aging-related metabolic disorders through modulating gut microbiome-T cell axis.

Aging-related metabolic disorders seriously affect the lifespan of middle-aged and older people, potentially due to disruptions in the adaptive immune and gut microbial profiles. Dietary intervention offers a promising strategy for maintaining metabolic health. This study aimed to investigate the ameliorative effect of 2'-fucosyllactose (2'-FL) on aging-induced metabolic dysfunction and the underlying mechanisms. The results revealed that 2'-FL significantly relieved aging-related metabolic disorders, including weight gain, lipid deposition, dyslipidemia, glucose intolerance, systemic inflammation, and abnormal hepatic metabolism. Flow cytometry analysis revealed a significant reduction in T cytotoxic (Tc), T helper (Th), and regulatory T (Treg) cells and a significant increase in Th17 cells in aged mice, while 2'-FL relieved the aging-induced proportional changes in Th and Th17 subtypes. The aging intestinal microecology was characterized by higher Th17/Treg ratios, impaired gut barrier function, lower gut bacterial diversity, decreased abundance of beneficial genera including Ligilactobacillus, Colidextribacter, Mucispirillum, and Lachnoclostridium, and increased abundance of harmful bacteria including Turicibacter and Desulfovibrio, which was ameliorated by 2'-FL treatment. These findings highlight that 2'-FL is an ideal dietary prebiotic for improving aging-related metabolic disorders by modulating both the adaptive immune system and the gut microbial profile.

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来源期刊
Aging Cell
Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology
自引率
2.60%
发文量
212
期刊介绍: Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.
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