{"title":"铱催化邻羟基苯基烯酮还原合成苯丙酮及其在 3-甲基铬酮合成中的应用。","authors":"Zhi Tu , Jie-Ping Wan , Li Wei , Yunyun Liu","doi":"10.1039/d4ob01359j","DOIUrl":null,"url":null,"abstract":"<div><div>A method of reducing <em>o</em>-hydroxyphenyl enaminones with silane as the reductant to provide <em>o</em>-hydroxyl propiophenones has been achieved with iridium catalysis. The reduction reactions were found to proceed <em>via</em> the assistance of the hydroxyl group in the phenyl ring. In addition, the <em>o</em>-hydroxyl propiophenone products were used for the easy synthesis of 3-methyl chromones by directly incorporating <em>N</em>,<em>N</em>-dimethyl formamide dimethyl acetal (DMF-DMA) without using any catalyst.</div></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis of propiophenones and their application in 3-methyl chromone synthesis†\",\"authors\":\"Zhi Tu , Jie-Ping Wan , Li Wei , Yunyun Liu\",\"doi\":\"10.1039/d4ob01359j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A method of reducing <em>o</em>-hydroxyphenyl enaminones with silane as the reductant to provide <em>o</em>-hydroxyl propiophenones has been achieved with iridium catalysis. The reduction reactions were found to proceed <em>via</em> the assistance of the hydroxyl group in the phenyl ring. In addition, the <em>o</em>-hydroxyl propiophenone products were used for the easy synthesis of 3-methyl chromones by directly incorporating <em>N</em>,<em>N</em>-dimethyl formamide dimethyl acetal (DMF-DMA) without using any catalyst.</div></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1477052024008322\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024008322","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis of propiophenones and their application in 3-methyl chromone synthesis†
A method of reducing o-hydroxyphenyl enaminones with silane as the reductant to provide o-hydroxyl propiophenones has been achieved with iridium catalysis. The reduction reactions were found to proceed via the assistance of the hydroxyl group in the phenyl ring. In addition, the o-hydroxyl propiophenone products were used for the easy synthesis of 3-methyl chromones by directly incorporating N,N-dimethyl formamide dimethyl acetal (DMF-DMA) without using any catalyst.
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