Fe(III)-catalyzed p-selective C-H bond chalcogenation of phenols.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-20 DOI:10.1039/d4ob01382d

Biprajit Paul, Sayak Ghosh, Surajit Das, Indranil Chatterjee

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引用次数: 0

摘要

本研究介绍了一种高效、环保和可扩展的苯酚对选择性 C-X（X = Se/S）键形成方案，该方案采用了富集的、毒性较低的铁(III)催化剂和绿色溶剂乙醇，无需使用任何导向模板、稳定配体、氧化剂或添加剂。该方法的主要吸引力在于：在温和的有氧反应条件下，具有令人印象深刻的对选择性和适度至良好的产率、广泛的官能团兼容性，以及可对产品进行合成改性，使其成为具有附加值的分子。

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Fe(III)-catalyzed p-selective C-H bond chalcogenation of phenols.

An efficient, eco-friendly, and scalable protocol has been introduced for the p-selective C-X (X = Se/S) bond formation of phenols employing earth-abundant, less-toxic Fe(III)-catalysts and the green solvent ethanol without using any directing template, stabilizing ligands, oxidants, or additives. The key attraction lies in the impressive p-selectivity with moderate to good yields, wide functional group compatibility under mild aerobic reaction conditions, and the synthetic modification of the products towards value-added molecules.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.