铜催化的乙炔基苯并恶嗪酮与硫醇的串联环化反应：2-硫代亚甲基吲哚的简易构建。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-23 DOI:10.1039/d4ob01164c

Lei Song, Fu-Qiang Li, Xiao-Han Qiu, Guo-Zhen Wei, Hui-Yu Chen, Ming Bian, Yu-Ning Gao, Zhen-Jiang Liu

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引用次数: 0

摘要

首次成功开发了铜催化的乙炔基苯并恶嗪酮与硫醇的脱羧环化反应。一个很少被研究的亚烯铜中间体α-加成过程促进了这一反应。利用这一方案，获得了一系列 2-硫亚甲基吲哚化合物。该方法具有反应条件温和、催化剂便宜、产率高和底物相容性广等显著优势。

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Copper-catalyzed tandem cyclization reaction of ethynylbenzoxazinones and thiols: facile construction of 2-thiomethylene indoles.

The first successful copper-catalyzed decarboxylative cyclization reaction of ethynylbenzoxazinones and thiols has been developed. A rarely studied α-addition process to a copper-allenylidene intermediate promoted this reaction. Using this protocol, a range of 2-thiomethylene indole compounds have been obtained. This methodology offers significant advantages including mild reaction conditions, cheap catalysts, good yields and broad substrate compatibility.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.