影响肥胖的早期生活因素和复杂解决方案的必要性

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL
Kylie D. Hesketh, Miaobing Zheng, Karen J. Campbell
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引用次数: 0

摘要

肥胖症的发病率随着年龄的增长而增加,但即使在生命早期也很明显。众所周知,幼儿期是影响未来健康发展的关键时期。即便如此,对这一阶段肥胖症以及影响肥胖症发展的因素的关注也是在过去二十年才出现的。此外,在这一领域还缺乏能推动该领域发展的反复工作。肥胖症是一种复杂的疾病,涉及不同层面的多重影响因素:个体和生物层面、社会文化层面以及环境和系统层面。本综述简要概述了这些因素的证据,重点关注生命早期的具体方面。通过强调各种影响因素(包括因果关系和风险标记)之间复杂的相互作用网络,我们突出了该疾病的复杂性。早期生活领域的许多工作仍然是观察性的,许多干预研究由于只关注单一的影响因素而受到限制,解决方法也不连贯。然而,由于肥胖症的复杂性,有必要在受孕后的头 2000 天及以后的时间里,采取协调的多重点解决方案和联合行动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early life factors that affect obesity and the need for complex solutions

Early life factors that affect obesity and the need for complex solutions

The prevalence of obesity increases with age but is apparent even in early life. Early childhood is a critical period for development that is known to influence future health. Even so, the focus on obesity in this phase, and the factors that affect the development of obesity, has only emerged over the past two decades. Furthermore, there is a paucity of iterative work in this area that would move the field forward. Obesity is a complex condition involving the interplay of multiple influences at different levels: the individual and biological level, the sociocultural level, and the environmental and system levels. This Review provides a brief overview of the evidence for these factors with a focus on aspects specific to early life. By spotlighting the complex web of interactions between the broad range of influences, both causal and risk markers, we highlight the complex nature of the condition. Much work in the early life field remains observational and many of the intervention studies are limited by a focus on single influences and a disjointed approach to solutions. Yet the complexity of obesity necessitates coordinated multi-focused solutions and joined-up action across the first 2,000 days from conception, and beyond.

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来源期刊
CiteScore
7.90
自引率
7.30%
发文量
215
审稿时长
3.5 months
期刊介绍: Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.
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