棕色脂肪组织对抗白血病

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-09-20 DOI:10.1038/s41574-024-01043-2

Pamela Fischer-Posovszky, Julia Zinngrebe

{"title":"棕色脂肪组织对抗白血病","authors":"Pamela Fischer-Posovszky, Julia Zinngrebe","doi":"10.1038/s41574-024-01043-2","DOIUrl":null,"url":null,"abstract":"Brown adipocytes are increasingly recognized as a promising therapeutic target for metabolic disorders. Research published in Advanced Science now presents evidence that these cells might also be useful for leukaemia therapy. The study demonstrates that activation of brown adipocytes deprives leukaemia cells of glucose, which reveals a potential new avenue for leukaemia treatment.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Brown adipose tissue fights the battle against leukaemia\",\"authors\":\"Pamela Fischer-Posovszky, Julia Zinngrebe\",\"doi\":\"10.1038/s41574-024-01043-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Brown adipocytes are increasingly recognized as a promising therapeutic target for metabolic disorders. Research published in Advanced Science now presents evidence that these cells might also be useful for leukaemia therapy. The study demonstrates that activation of brown adipocytes deprives leukaemia cells of glucose, which reveals a potential new avenue for leukaemia treatment.\",\"PeriodicalId\":31,\"journal\":{\"name\":\"Chemical Research in Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Research in Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41574-024-01043-2\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Research in Toxicology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41574-024-01043-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

棕色脂肪细胞被越来越多的人认为是治疗代谢性疾病的理想靶点。发表在《先进科学》（Advanced Science）上的研究现在提供了证据，证明这些细胞也可用于白血病治疗。研究表明，激活棕色脂肪细胞可使白血病细胞无法获得葡萄糖，这为白血病治疗提供了一条潜在的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Brown adipose tissue fights the battle against leukaemia

查看原文本刊更多论文

Brown adipose tissue fights the battle against leukaemia

Brown adipocytes are increasingly recognized as a promising therapeutic target for metabolic disorders. Research published in Advanced Science now presents evidence that these cells might also be useful for leukaemia therapy. The study demonstrates that activation of brown adipocytes deprives leukaemia cells of glucose, which reveals a potential new avenue for leukaemia treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.