选择性氢化硝基烯烃的绿色、廉价和稳健方法

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-09-16 DOI:10.1016/j.tet.2024.134269

Piao Ding , Eman Fayad , Ola A. Abu Ali , Hua-Li Qin

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引用次数: 0

摘要

利用一种市场上可买到的镍作为有效催化剂，在克级规模内将硝基烯烃氢化成伯胺，而无需额外的柱层析纯化。这种新颖的合成氢化策略具有底物范围广、条件温和以及在室温水介质中操作简单等特点。进一步转化的结果是获得了重要的含胺药物和医药中间体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A green, cheap and robust method for selective hydrogenation of nitroarenes

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A green, cheap and robust method for selective hydrogenation of nitroarenes

A commercially available nickel was utilized as an effective catalyst for the exclusive hydrogenation of nitroarenes to primary anilines in gram-scale without additional column chromatographic purification. This novel synthetic hydrogenation strategy features wide substrate scope, mild conditions and operational simplicity in aqueous media at room temperature. Further transformations resulted in the delivery of important amine-containing drugs and pharmaceutical intermediates.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.