瑞马吡嗪，一种新的外源性滤过标志物，以及更广泛地使用测量的 GFR

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-09-18 DOI:10.1016/j.kint.2024.07.019

Marcelle Tuttle , Andrew S. Levey

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引用次数: 0

摘要

要评估测定的肾小球滤过率，就必须清除血浆或尿液中的外源性滤过标记物。虽然有多种方法可供选择，但由于其复杂性、测量误差和标准化程度有限，没有一种方法得到广泛应用。最近，一项研究验证了一种新的外源性滤过标记物--雷马吡嗪的血浆清除率，该标记物可通过其透皮荧光进行检测，从而有可能简化操作过程并增加测量肾小球滤过率的机会。

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Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR

Plasma or urinary clearance of exogenous filtration markers is required for assessment of measured glomerular filtration rate. Although multiple methods are available, none is widely used because of their complexity, each has measurement error, and standardization is limited. Recently, a study validated the plasma clearance of a new exogenous filtration marker, relmapirazin, which can be detected by its transdermal fluorescence, potentially simplifying the procedure and increasing access to measured glomerular filtration rate.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.