灵长类动物的上丘参与抽象的高阶认知。

IF 21.2 1区 医学 Q1 NEUROSCIENCES
Barbara Peysakhovich, Ou Zhu, Stephanie M. Tetrick, Vinay Shirhatti, Alessandra A. Silva, Sihai Li, Guilhem Ibos, Matthew C. Rosen, W. Jeffrey Johnston, David J. Freedman
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引用次数: 0

摘要

上丘是一个进化保守的中脑区域,它被认为介导空间定向,包括眼球回旋运动和隐蔽的空间注意。在这里,我们揭示了上丘在高阶认知中的作用,与其在空间定向中的作用无关。我们训练猕猴完成一项抽象的视觉分类任务,该任务既不涉及指示性眼球运动,也不涉及隐蔽注意力的差异。我们比较了上丘和后顶叶皮层的神经活动,后顶叶皮层以前曾被证明对抽象分类决策有因果关系。上丘表现出对已学视觉类别的稳健编码,这种编码比后顶叶皮层更强,而且在这两个区域中产生的潜伏期相似。此外,上丘的失活会明显影响动物的分类决策。这些结果表明,灵长类动物的上丘介导了抽象的、高阶的认知过程,而这些过程历来被认为是由新皮层介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Primate superior colliculus is causally engaged in abstract higher-order cognition

Primate superior colliculus is causally engaged in abstract higher-order cognition
The superior colliculus is an evolutionarily conserved midbrain region that is thought to mediate spatial orienting, including saccadic eye movements and covert spatial attention. Here, we reveal a role for the superior colliculus in higher-order cognition, independent of its role in spatial orienting. We trained rhesus macaques to perform an abstract visual categorization task that involved neither instructed eye movements nor differences in covert attention. We compared neural activity in the superior colliculus and the posterior parietal cortex, a region previously shown to causally contribute to abstract category decisions. The superior colliculus exhibits robust encoding of learned visual categories, which is stronger than in the posterior parietal cortex and arises at a similar latency in the two areas. Moreover, inactivation of the superior colliculus markedly impaired animals’ category decisions. These results demonstrate that the primate superior colliculus mediates abstract, higher-order cognitive processes that have traditionally been attributed to the neocortex. Neuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization behavior, independent of its role in spatial orienting.
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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