H. Lucron , M. Brard , J. D’orazio , L. Long , A. Le Harrivel De Gonneville , S. Tuttle , N. Elenga , J. Inamo , D. Bonnet , R. Banydeen
{"title":"拉丁美洲和加勒比地区婴儿先天性心脏病死亡率和单室心：法属圭亚那人口研究","authors":"H. Lucron , M. Brard , J. D’orazio , L. Long , A. Le Harrivel De Gonneville , S. Tuttle , N. Elenga , J. Inamo , D. Bonnet , R. Banydeen","doi":"10.1016/j.acvd.2024.07.047","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Except for projections from the Global Burden of Disease (GBD) study, congenital heart disease (CHD) burden remains undetermined in Latin America and Caribbean (LAC), especially for complex types such as functionally univentricular hearts (FUH) responsible for higher disease morbidity and mortality.</p></div><div><h3>Objective</h3><p>To describe CHD prevalence, characteristics and related infant mortality in French Guiana, a LAC territory.</p></div><div><h3>Methods</h3><p>Population-based registry analysis of all fetal and live birth (LB) CHD cases from January 2012 to December 2016.</p></div><div><h3>Results</h3><p>Overall, 231 CHD were diagnosed, among which 56 fetal diagnoses and 215 resulting LB. Among all CHD (<em>n</em> <!-->=<!--> <!-->231), there were 18.6% of chromosomal or genetic anomalies, and 6.5% of termination of pregnancy for fetal anomaly. Total and LB CHD prevalence were respectively 68.4 [95% CI: 67.9–68.8] and 65.2 [95% CI: 64.7–65.7] per 10,000, similar to GBD projections for TLA. The total infant mortality in the study sample was 9.4/10,000 LB [95% CI: 9.1–9.7]. Children with FUH presented the highest mortality rates. When compared to mainland France, total FUH prevalence for French Guiana was significantly higher (<em>P</em> <!-->=<!--> <!-->0.03), as were LB FUH prevalence and related infant mortality respectively two to three-fold higher (<em>P</em> <!--><<!--> <!-->0.01). However, no significant difference was observed for FUH prevalence when compared to GBD projections for TLA. FUH infant mortality could not be contrasted due to the lack of GBD data.</p></div><div><h3>Conclusion</h3><p>This first population-based study ever performed in this part of the world suggests a distinct profile for CHD in the LAC region, with elevated prevalence and mortality rates linked to FUH. Another potential determinant of the excess mortality risk might be the frequent presence of chromosomal or genetic anomalies. This constitutes a stepping-stone towards better understanding CHD burden and underlying specificities while providing future keys towards reducing infant mortality in French Guiana and others surrounding countries.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Infant congenital cardiac mortality and univentricular hearts in Latin America and Caribbean: A population-based study in French Guiana\",\"authors\":\"H. Lucron , M. Brard , J. D’orazio , L. Long , A. Le Harrivel De Gonneville , S. Tuttle , N. Elenga , J. Inamo , D. Bonnet , R. Banydeen\",\"doi\":\"10.1016/j.acvd.2024.07.047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Except for projections from the Global Burden of Disease (GBD) study, congenital heart disease (CHD) burden remains undetermined in Latin America and Caribbean (LAC), especially for complex types such as functionally univentricular hearts (FUH) responsible for higher disease morbidity and mortality.</p></div><div><h3>Objective</h3><p>To describe CHD prevalence, characteristics and related infant mortality in French Guiana, a LAC territory.</p></div><div><h3>Methods</h3><p>Population-based registry analysis of all fetal and live birth (LB) CHD cases from January 2012 to December 2016.</p></div><div><h3>Results</h3><p>Overall, 231 CHD were diagnosed, among which 56 fetal diagnoses and 215 resulting LB. Among all CHD (<em>n</em> <!-->=<!--> <!-->231), there were 18.6% of chromosomal or genetic anomalies, and 6.5% of termination of pregnancy for fetal anomaly. Total and LB CHD prevalence were respectively 68.4 [95% CI: 67.9–68.8] and 65.2 [95% CI: 64.7–65.7] per 10,000, similar to GBD projections for TLA. The total infant mortality in the study sample was 9.4/10,000 LB [95% CI: 9.1–9.7]. Children with FUH presented the highest mortality rates. When compared to mainland France, total FUH prevalence for French Guiana was significantly higher (<em>P</em> <!-->=<!--> <!-->0.03), as were LB FUH prevalence and related infant mortality respectively two to three-fold higher (<em>P</em> <!--><<!--> <!-->0.01). However, no significant difference was observed for FUH prevalence when compared to GBD projections for TLA. FUH infant mortality could not be contrasted due to the lack of GBD data.</p></div><div><h3>Conclusion</h3><p>This first population-based study ever performed in this part of the world suggests a distinct profile for CHD in the LAC region, with elevated prevalence and mortality rates linked to FUH. Another potential determinant of the excess mortality risk might be the frequent presence of chromosomal or genetic anomalies. 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Infant congenital cardiac mortality and univentricular hearts in Latin America and Caribbean: A population-based study in French Guiana
Introduction
Except for projections from the Global Burden of Disease (GBD) study, congenital heart disease (CHD) burden remains undetermined in Latin America and Caribbean (LAC), especially for complex types such as functionally univentricular hearts (FUH) responsible for higher disease morbidity and mortality.
Objective
To describe CHD prevalence, characteristics and related infant mortality in French Guiana, a LAC territory.
Methods
Population-based registry analysis of all fetal and live birth (LB) CHD cases from January 2012 to December 2016.
Results
Overall, 231 CHD were diagnosed, among which 56 fetal diagnoses and 215 resulting LB. Among all CHD (n = 231), there were 18.6% of chromosomal or genetic anomalies, and 6.5% of termination of pregnancy for fetal anomaly. Total and LB CHD prevalence were respectively 68.4 [95% CI: 67.9–68.8] and 65.2 [95% CI: 64.7–65.7] per 10,000, similar to GBD projections for TLA. The total infant mortality in the study sample was 9.4/10,000 LB [95% CI: 9.1–9.7]. Children with FUH presented the highest mortality rates. When compared to mainland France, total FUH prevalence for French Guiana was significantly higher (P = 0.03), as were LB FUH prevalence and related infant mortality respectively two to three-fold higher (P < 0.01). However, no significant difference was observed for FUH prevalence when compared to GBD projections for TLA. FUH infant mortality could not be contrasted due to the lack of GBD data.
Conclusion
This first population-based study ever performed in this part of the world suggests a distinct profile for CHD in the LAC region, with elevated prevalence and mortality rates linked to FUH. Another potential determinant of the excess mortality risk might be the frequent presence of chromosomal or genetic anomalies. This constitutes a stepping-stone towards better understanding CHD burden and underlying specificities while providing future keys towards reducing infant mortality in French Guiana and others surrounding countries.
期刊介绍：
The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.
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