方坦发绀前期:年轻患者方坦运动后心输出量的关键因素

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
P. David , A.S. Chaussade , L. Iserin , S. Malekzadeh-Milani , F. Bajolle , D. Bonnet , D. Khraiche , A. Legendre
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引用次数: 0

摘要

背景大多数丰坦循环患者在运动时很难增加心输出量,这影响了他们的有氧能力、对训练的反应和生活质量。心脏表现不佳影响了他们的有氧能力、对训练的反应和生活质量。我们试图找出影响他们运动心脏表现的方坦前因素和管理因素。方法 我们回顾性地收集了 57 名连续接受心肺运动测试的年轻方坦患者(中位年龄 14.7 岁)的方坦前后解剖学、病理学和血液动力学数据。我们使用可测量峰值心脏指数(pCI)的胸腔生物电阻抗装置研究了他们的运动心脏性能。在多变量模型中,pCI 受紫绀持续时间的负面影响(B = -0.240;P = 0.0002)。峰值指数搏出量(pSVi)受诺伍德程序(B = -8.415;P = 0.005)和发绀持续时间(B = -1.591; P = 0.0002)的负面影响,峰值心率(pHR)受芳坦前外周血氧饱和度(B = 0.602 P = 0.009)的负面影响。紫绀持续时间≤ 6.9 年可预测 pSVi≥ 45 mL/m2(AUC = 0.747;P = 0.001)。此外,pSVi 和 pHR 与方坦后心室充盈压(post-VFP)相关(分别为 rp = -0.539,P = 0.012 和 rp = -0.552;P = 0.010),post-VFP 与双向腔肺分流持续时间相关(rs = 0.结论在年轻的Fontan患者中,Fontan术前紫绀持续时间和外周血氧饱和度低可能通过增加心室充盈压影响心脏运动表现的两个组成部分。缩短紫绀持续时间有助于长期保持心脏功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The pre-Fontan cyanosis period: Key factor in post-Fontan exercise cardiac output in young patients

Background

Most patients with Fontan circulation struggle to increase cardiac output during exercise affecting aerobic capacity, response to training and quality of life. This poor cardiac performance affects their aerobic capacity, their response to training and their quality of life. We sought to identify the pre-Fontan and managerial factors that influence their exercise cardiac performance.

Methods

We retrospectively collected pre and post-Fontan anatomical, anamnestic and hemodynamic data in 57 consecutive young Fontan patients (median age 14.7 years) who underwent cardiopulmonary exercise test. We studied their exercise cardiac performance using a thoracic bioelectrical impedance device that allows measurement of the peak cardiac index (pCI).

Results

The median age at Fontan was 6.4 ± 3 years. In multivariable models, pCI was negatively influenced by cyanosis duration (B = −0.240; P = 0.0002). Peak indexed stroke volume (pSVi) was negatively influenced by Norwood procedure (B = -8.415; P = 0.005) and cyanosis duration (B = −1.591; P = 0.0002) and peak heart rate (pHR) by pre-Fontan peripheral oxygen saturation (B = 0.602 P = 0.009). Cyanosis duration  6.9 years predicted a pSVi  45 mL/m2 (AUC = 0.747; P = 0.001). Furthermore, pSVi and pHR were correlated with post-Fontan ventricular filling pressure (post-VFP) (respectively rp = −0.539, p = 0.012 and rp = −0.552; P = 0.010) and post-VFP was correlated with bidirectional cavopulmonary shunt duration (rs = 0.498, P = 0.023).

Conclusion

In young Fontan patients, the duration of cyanosis and low peripheral oxygen saturation prior to the Fontan procedure affect both components of cardiac exercise performance probably through increased ventricular filling pressure. Shortening the duration of cyanosis could help preserve cardiac performance in the long term.

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来源期刊
Archives of Cardiovascular Diseases
Archives of Cardiovascular Diseases 医学-心血管系统
CiteScore
4.40
自引率
6.70%
发文量
87
审稿时长
34 days
期刊介绍: The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.
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