失眠与甲状腺疾病之间的因果关系：双向孟德尔随机研究

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-09-18 DOI:10.1002/brb3.70046

Zhonghui Li, Zonghang Jia, Peng Zhou, Qingqing He

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引用次数: 0

摘要

以往的研究发现，甲状腺疾病与失眠之间存在一定的相关性，但二者之间的因果关系尚不明确。本研究旨在探讨失眠与五种甲状腺疾病（甲状腺功能亢进症、甲状腺功能减退症、甲状腺炎、甲状腺结节和甲状腺癌）之间的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study

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Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study

Objective

Some correlations between thyroid disorders and insomnia have been found in previous studies; however, the causal relationship between them is unclear. The aim of this study was to investigate the causal relationship between insomnia and five thyroid disorders (hyperthyroidism, hypothyroidism, thyroiditis, thyroid nodules, and thyroid cancer).

Methods

We assessed the causal relationship between insomnia and thyroid disorders using inverse variance weighted, weighted median, and Mendelian randomization (MR)-Egger analyses in MR analyses and then used inverse MR analyses to assess the causal relationship between thyroid disorders and insomnia.

Results

MR analysis showed that insomnia did not increase the risk of hyperthyroidism, hypothyroidism, thyroiditis, thyroid nodules, and thyroid cancer. However, reverse MR analysis showed that thyroid cancer increased the risk of insomnia (OR = 1.01, 95%CI: 1.00–1.02, p = .01), and the other four thyroid disorders had no direct causal relationship with insomnia. Sensitivity analyses indicated that the results were robust and no pleiotropy or heterogeneity was detected.

Conclusion

This study did not find evidence of a bidirectional causal relationship between genetically predicted insomnia and hyperthyroidism, hypothyroidism, thyroiditis, and thyroid nodules. However, we found that although insomnia does not increase the risk of thyroid cancer, thyroid cancer does increase the risk of insomnia.

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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