利用 SNH 和点击反应修饰 2-氨基-5-溴甲基-3-(乙氧羰基)吡嗪 1-氧化物

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-09-19 DOI:10.1007/s11172-024-4348-x

V. E. Petrova, I. S. Kovalev, G. V. Zyryanov, V. L. Rusinov

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引用次数: 0

摘要

研究了 2-氨基-5-溴甲基-3-(乙氧羰基)吡嗪 1-氧化物及其衍生物系列中的 SNH 反应和点击反应在合成叶酸远缘类似物和荧光团中的适用性。目标产物的合成率高达 81%，并通过 1H NMR 光谱和质谱分析证实了它们的结构。

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Modification of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide using SNH and click reactions

The applicability of S_N^H and click reactions in the series of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide and its derivatives for the synthesis of distant analogs of folic acid and fluorophores was studied. The target products were synthesized in the yields up to 81%, and their structures were proved by ¹H NMR spectroscopy and mass spectrometry.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.