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引用次数: 0
摘要
在高阶真核生物中，DNA甲基化作为一种表观遗传标记的有丝分裂遗传性已经确立了40年。现在，DNA甲基化组与有丝分裂的相互作用被认为是双向的、高度交织的。各种表观遗传撰写器、擦除器和调节器形成了可感知的复制甲基化动态。本综述探讨了DNA甲基化有丝分裂传递的原理和复杂性，强调了在分析发育和疾病中DNA甲基化动态时对有丝分裂老化的认识。我们回顾了 DNA 甲基化变化如何改变有丝分裂增殖能力，并与癌症等与年龄相关的疾病有关。我们将复制表突变与干细胞功能障碍、炎症反应、癌症风险和表观遗传时钟联系起来，讨论了 DNA 甲基化在健康和疾病中的致病作用。
On correlative and causal links of replicative epimutations
The mitotic inheritability of DNA methylation as an epigenetic marker in higher-order eukaryotes has been established for >40 years. The DNA methylome and mitotic division interplay is now considered bidirectional and highly intertwined. Various epigenetic writers, erasers, and modulators shape the perceived replicative methylation dynamics. This Review surveys the principles and complexity of mitotic transmission of DNA methylation, emphasizing the awareness of mitotic aging in analyzing DNA methylation dynamics in development and disease. We reviewed how DNA methylation changes alter mitotic proliferation capacity, implicating age-related diseases like cancer. We link replicative epimutation to stem cell dysfunction, inflammatory response, cancer risks, and epigenetic clocks, discussing the causative role of DNA methylation in health and disease.
期刊介绍：
Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology.
Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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