逐渐形成有利于突变效应的分布

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-09-14 DOI:10.1016/j.tig.2024.07.009

David G. King

引用次数: 0

摘要

串联重复 DNA 序列似乎是唯一能够产生大量重复数突变的序列，这些突变具有潜在的有利适应效应分布。虽然了解有害突变、中性突变和有益突变的发生率和相对比例是了解进化性的基础，但对适应性的分析通常会忽略串联重复序列中产生的小效应突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evolving a favorable distribution for mutation effects

Tandem-repeat DNA sequences appear to be singularly capable of yielding abundant repeat-number mutations with a potentially advantageous distribution of fitness effects. Although knowing the rates and relative proportions of deleterious, neutral and beneficial mutations is fundamental for understanding evolvability, analysis of adaptation routinely overlooks small-effect mutations arising in tandem repeats.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.