少突胶质细胞系细胞的自噬以年龄依赖性方式控制少突胶质细胞数量和髓鞘完整性

IF 5.9 2区 医学 Q1 NEUROSCIENCES
Hong Chen, Gang Yang, De-En Xu, Yu-tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma
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引用次数: 0

摘要

少突胶质细胞系细胞,包括少突胶质前体细胞(OPCs)和少突胶质细胞(OLs),是建立和维持大脑回路的关键。自噬是一种保持细胞器质量和蛋白稳态的保守过程。自噬在少突胶质细胞系细胞中的作用仍不清楚。本研究表明,在大脑衰老过程中,自噬是维持 OPCs/OLs 数量和髓鞘完整性的必要条件。少突胶质细胞系细胞中的自噬失活会增加发育中大脑中OPCs/OLs的数量,同时会加剧大脑衰老过程中OPCs/OLs的损失。少突胶质细胞系细胞的自噬失活会影响髓鞘碱性蛋白(MBP)的周转。它导致 MBP 以多聚体的形式在细胞质中聚集,无法融入完整的髓鞘,这与内细胞循环减弱有关。少突胶质细胞系细胞的自噬失活会损害髓鞘完整性并导致脱髓鞘。因此,这项研究表明,在衰老过程中,自噬需要通过控制髓鞘成分的周转来维持髓鞘的质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner

Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner

Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.

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来源期刊
Neuroscience bulletin
Neuroscience bulletin NEUROSCIENCES-
CiteScore
7.20
自引率
16.10%
发文量
163
审稿时长
6-12 weeks
期刊介绍: Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.
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