通过末端乙炔与 3-甲氧基丙腈反应，在二茂钛催化下选择性合成 2,4-二烷基-6-(2-甲氧基乙基)吡啶

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-09-19 DOI:10.1007/s11172-024-4342-3

M. G. Shaibakova, E. I. Titova, L. K. Dil’mukhametova, I. R. Ramazanov

引用次数: 0

摘要

在 EtAlCl2、Mg 和 Cp2TiCl2 (10 mol.%) 的存在下，通过末端乙炔与 3-甲氧基丙腈的反应，开发了一种选择性单锅法合成 2,4-二烷基-6-(2-甲氧基乙基)吡啶，收率为 70-82%。

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Titanocene-catalyzed selective synthesis of 2,4-dialkyl-6-(2-methoxyethyl)pyridines by the reaction of terminal acetylenes with 3-methoxypropionitrile

A selective one-pot method was developed for the synthesis of 2,4-dialkyl-6-(2-methoxyethyl)pyridines in yields of 70–82% by the reaction of terminal acetylenes with 3-methoxypropionitrile in the presence of EtAlCl₂, Mg, and Cp₂TiCl₂ (10 mol.%).

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.