生长激素替代疗法对成人生长激素缺乏症患者的长期代谢有效性和安全性:日本一项单一机构研究

IF 3.3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yuka Oi-Yo, Masaaki Yamamoto, Shin Urai, Hironori Bando, Yuka Ohmachi, Yuma Motomura, Masaki Kobatake, Yasutaka Tsujimoto, Yuriko Sasaki, Masaki Suzuki, Naoki Yamamoto, Michiko Takahashi, Genzo Iguchi, Wataru Ogawa, Yutaka Takahashi, Hidenori Fukuoka
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引用次数: 0

摘要

目的阐明生长激素替代疗法(GHRT)对日本成人生长激素缺乏症(AGHD)患者的长期疗效和安全性。我们共招募了 110 名接受 GHRT 的 AGHD 患者。从研究开始每年收集一次临床和实验室数据。结果在所有患者中,46.4%为男性,70.9%为成人型GHD,随访时间长达196个月,中位数为68个月。胰岛素样生长因子-1标准偏差评分在GHRT开始后有所增加,并在超过11年的时间里保持不变。17 名患者的随访时间超过 11 年。体重指数有所上升。腰围在短期内有所减少,但在长期内有所增加。在开始接受 GHRT 1-5 年后,舒张压下降,而在接受 GHRT 11 年后,收缩压上升。此外,还观察到低密度脂蛋白胆固醇长期下降,高密度脂蛋白胆固醇上升,天门冬氨酸氨基转移酶和丙氨酸氨基转移酶水平下降。3 年后,糖化血红蛋白水平有所上升。开始接受 GHRT 3 年后,腰椎和整个髋关节的骨质密度明显增加。结论我们在 16 年的长期随访中证明了 GHRT 在日本 AGHD 患者中的代谢有效性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Long-term metabolic effectiveness and safety of growth hormone replacement therapy in patients with adult growth hormone deficiency: a single-institution study in Japan

Long-term metabolic effectiveness and safety of growth hormone replacement therapy in patients with adult growth hormone deficiency: a single-institution study in Japan

Purpose

To elucidate the long-term efficacy and safety of growth hormone replacement therapy (GHRT) in Japanese patients with adult growth hormone deficiency (AGHD).

Methods

We conducted a retrospective study. A total of 110 patients with AGHD receiving GHRT were enrolled. Clinical and laboratory data were collected annually from the beginning of the study. Statistical analysis was performed using a linear mixed-effects model.

Results

Of all patients, 46.4% were males, 70.9% had adult-onset GHD, and follow-up was up to 196 months, with a median of 68 months. The insulin-like growth factor-1 standard deviation score increased after the start of GHRT and remained constant for more than 11 years. Seventeen patients were followed up for more than 11 years. The body mass index increased. Waist circumference decreased in the short term but increased in the long term. The diastolic blood pressure decreased 1–5 years after the start of GHRT, and the systolic blood pressure increased 11 years after GHRT. Moreover, a long-term decrease in low-density lipoprotein cholesterol, an increase in high-density lipoprotein cholesterol, and a decrease in aspartate aminotransferase and alanine aminotransferase levels were observed. The glycosylated hemoglobin level increased after 3 years. The bone mineral density in the lumbar spine and total hip increased significantly 3 years after the start of GHRT. Finally, the number of adverse events was eight.

Conclusion

We demonstrated the metabolic effectiveness and safety of GHRT in Japanese patients with AGHD over a long follow-up period of 16 years.

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来源期刊
Pituitary
Pituitary 医学-内分泌学与代谢
CiteScore
7.10
自引率
7.90%
发文量
90
审稿时长
6 months
期刊介绍: Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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