以人群流行率为指导，明智地使用精确的荧光原位杂交面板，可帮助实用地检测临床上可靶向的费城染色体样急性淋巴细胞白血病融合：系统综述

IF 3.6 3区医学 Q1 PATHOLOGY

Pathology Pub Date : 2024-09-07 DOI:10.1016/j.pathol.2024.08.001

Jane Thompson, Geoffrey Thompson, Deborah White, David Yeung

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引用次数: 0

摘要

在现实世界中，费城染色体样急性淋巴细胞白血病（Ph-like ALL）的诊断仍然具有挑战性，因为定义复杂、诊断技术多样，而且涉及成本、专业知识和时间。我们总结了利用荧光杂交（FISH）技术诊断临床上重要的Ph-like ALL相关基因组病变的证据，该技术只针对临床上重要且可操作的病变，是一种方便且经济有效的诊断技术。

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Judicious use of precise fluorescence in situ hybridisation panels guided by population prevalence may assist pragmatic detection of clinically targetable Philadelphia chromosome-like acute lymphoblastic leukaemia fusions: a systematic review

Diagnosis of Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like ALL) in the real-world remains challenging because of definitional complexities, the diverse diagnostic techniques available and the cost, expertise and time involved. We summarise evidence for diagnosis of clinically important Ph-like ALL related genomic lesions using fluorescence hybridisation (FISH) targeting only clinically important and actionable lesions, an accessible and cost-effective diagnostic technique.

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来源期刊

Pathology 医学-病理学

CiteScore

6.50

自引率

2.20%

发文量

459

审稿时长

54 days

期刊介绍： Published by Elsevier from 2016 Pathology is the official journal of the Royal College of Pathologists of Australasia (RCPA). It is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including anatomical pathology, chemical pathology and biochemistry, cytopathology, experimental pathology, forensic pathology and morbid anatomy, genetics, haematology, immunology and immunopathology, microbiology and molecular pathology.