中国保定市男男性行为者和母婴传播病例中两种新型 HIV-1 CRF01_AE/ CRF07_BC 重组形式的特征。

IF 1.5 4区医学 Q4 IMMUNOLOGY

AIDS research and human retroviruses Pub Date : 2024-09-18 DOI:10.1089/aid.2024.0059

Jianru Jia,Huijuan Yang,Zhen Zhang,Haoxi Shi,Sisi Chen,Shi Penghui,Weiguang Fan

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引用次数: 0

摘要

CRF01_AE 和 CRF07_BC 是中国流行的 HIV-1 亚型。本研究报告了从河北省保定市一名男男性行为者（MSM）（BDD027）和一名母婴传播（MTCT）病例（BDL123）中分离出的两种新型 HIV-1 CRF01_AE/CRF07_BC重组型。重组断点分析表明，BDD027近全长基因组的重组模式由两个CRF07_BC片段插入CRF01_AE骨架组成，而BDL123近全长基因组的重组模式由一个CRF01_AE片段插入CRF07_BC骨架组成。这项研究表明了加强HIV-1分子流行病学特征监测的重要性，并强调了减少HIV-1在中国男男性行为人群和母婴传播人群中流行的紧迫性。

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Characterization of Two Novel HIV-1 CRF01_AE/ CRF07_BC Recombinant Forms Among Men Who Have Sex with Men and Mother-to-Child Transmission Cases in Baoding City, China.

CRF01_AE and CRF07_BC are predominant circulating HIV-1 subtypes in China. In this study, we report two novel HIV-1 CRF01_AE/CRF07_BC recombinant forms isolated from one man who has sex with men (MSM) (BDD027) and one mother-to-child transmission (MTCT) case (BDL123) in Baoding City, Hebei Province, China. The recombination breakpoint analysis showed that the recombination pattern of the near-full-length genome of BDD027 consisted of two CRF07_BC fragments inserted into a CRF01_AE backbone, while the recombination pattern of the near-full-length genome of BDL123 consisted of one CRF01_AE fragment inserted into a CRF07_BC backbone. This study demonstrates the importance of strengthening the monitoring of HIV-1 molecular epidemiological characteristics and emphasizes the urgent need to reduce the HIV-1 epidemic among MSM and MTCT populations in China.

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来源期刊

AIDS research and human retroviruses 医学-病毒学

CiteScore

3.10

自引率

6.70%

发文量

201

审稿时长

3-6 weeks

期刊介绍： AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.