阿尔茨海默病预后中的 T 淋巴细胞比例。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2024-09-16 DOI:10.12998/wjcc.v12.i26.6001

Matthew Willman,Gopi Patel,Brandon Lucke-Wold

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引用次数: 0

摘要

Bai 等人研究了 T 淋巴细胞比例在阿尔茨海默病（AD）预后中的预测价值。通过一项涉及 62 名阿尔茨海默病患者的回顾性研究，他们发现 T 淋巴细胞比例的下降与较差的预后相关，改良兰金量表评分越高，预后越差。虽然这项研究强调了T淋巴细胞比例作为预后标志物的潜力，但同时也表明需要进行更大规模的多中心研究，以提高普适性和有效性。此外，未来的研究还可以在评估预后时使用认知检查，并深入研究AD进展的免疫机制。尽管回顾性设计存在固有的局限性，但Bai等人的研究有助于了解免疫系统在AD预后中的作用，为在这一研究不足的领域进行进一步探索铺平了道路。

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T lymphocyte proportion in Alzheimer's disease prognosis.

Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease (AD) prognosis. Through a retrospective study involving 62 AD patients, they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis, as indicated by higher modified Rankin scale scores. While the study highlights the potential of T lymphocyte proportion as a prognostic marker, it suggests the need for larger, multicenter studies to enhance generalizability and validity. Additionally, future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD progression. Despite limitations inherent in retrospective designs, Bai et al's work contributes to understanding the immune system's role in AD prognosis, paving the way for further exploration in this under-researched area.

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.