以 SF6 为氟化试剂，利用可见光诱导光催化苯甲醇的脱氧氟化反应

IF 9.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2024-09-16 DOI:10.1039/d4gc03324h

Yi-Fan Zhang, Shan Zhu, Ya-Wen Zuo, Hang Liu, Ruo-Xing Jin, Xi-Sheng Wang

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引用次数: 0

摘要

氟原子能显著增强有机分子的代谢稳定性和生物利用度，因此氟化苄基是药物或生物活性分子中不可或缺的骨架。在此，我们采用六氟化硫（SF6）作为高效氟化试剂，在可见光 LED 光照射下，利用低剂量光催化剂 4CzIPN 实现了广泛存在的苄醇的亲核氟化反应。该反应与多种底物骨架兼容，对空气和湿气不敏感，实现了有效温室气体资源 SF6 的降解和利用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible light-induced photocatalytic deoxyfluorination of benzyl alcohol using SF6 as a fluorinating reagent

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Visible light-induced photocatalytic deoxyfluorination of benzyl alcohol using SF6 as a fluorinating reagent

As fluorine atoms significantly strengthen the metabolic stability and bioavailability of organic molecules, benzyl fluoride is found as an essential skeleton in pharmaceuticals or biologically active molecules. Here, we employ sulfur hexafluoride (SF₆) as an efficient fluorinating reagent, achieving nucleophilic fluorination of widely available benzyl alcohols under visible LED light irradiation with a low dosage of photocatalyst 4CzIPN. The reaction is compatible with several substrate backbones and is not air- or moisture-sensitive, realizing the degradation and utilization of SF₆, a potent greenhouse gas resource.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.