I.-M. Simek, A. Sturdza, J. Knoth, A Spannbauer, J. Bergler-Klein, M. Vögele-Kadletz, J. Widder, M. P. Schmid
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引用次数: 0
摘要
目的 宫颈癌引起的心脏转移非常罕见，也鲜有文献报道。我们旨在介绍一例新病例，并对现有文献进行系统总结。材料和方法按照 PRISMA（系统综述和 Meta 分析的首选报告项目）标准，系统检索了 PubMed、Scopus、Web of Science、Central 和 ClinicalTrials.gov。检索结果通过标题、摘要和全文进行筛选。此外，还筛选了所有被选中进行综述的论文的参考文献目录。心脏转移发生在宫颈癌的各个阶段和各个年龄组。从最初诊断到确诊心脏转移的中位时间为 12 个月。患者主要诉说呼吸困难和胸痛，60.8%的患者有病理性心电图（ECG）发现。心脏肿块最常通过经胸超声波检查发现。最常见的肿瘤组织学是鳞状细胞癌。化疗和手术是主要的治疗方式。诊断出心脏转移后的中位生存期为 3 个月。文献中描述的病例有 100 例，预后极差，临床治疗方法不明确。
Cardiac metastasis from cervical cancer is rare and only scarcely documented. We aim to present a new case and systematically summarize the available literature.
Materials and methods
PubMed, Scopus, Web of Science, Central, and ClinicalTrials.gov were systematically searched following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Results were screened via title, abstract, and full text. Additionally, the reference lists of all papers chosen for the review were screened.
Results
Eighty-one papers were identified, describing 86 cases in total. Cardiac metastasis occurred at all stages of cervical cancer and in all age groups. Median time from initial diagnosis to diagnosis of cardiac metastasis was 12 months. Patients mainly complained of dyspnea and chest pain, 60.8% had pathologic ECG (electrocardiographic) findings. The cardiac mass was most frequently detected by transthoracic echography. The most common tumor histology was squamous cell carcinoma. Chemotherapy and surgical interventions were the main treatment modalities. Median survival after diagnosis of cardiac metastasis was 3 months.
Conclusion
This largest review on cardiac metastases from cervical cancer confirmed the heart as a very infrequent site of metastasis. There are < 100 cases described in the literature, with very poor prognosis and undefined clinical management.
期刊介绍：
Strahlentherapie und Onkologie, published monthly, is a scientific journal that covers all aspects of oncology with focus on radiooncology, radiation biology and radiation physics. The articles are not only of interest to radiooncologists but to all physicians interested in oncology, to radiation biologists and radiation physicists. The journal publishes original articles, review articles and case studies that are peer-reviewed. It includes scientific short communications as well as a literature review with annotated articles that inform the reader on new developments in the various disciplines concerned and hence allow for a sound overview on the latest results in radiooncology research.
Founded in 1912, Strahlentherapie und Onkologie is the oldest oncological journal in the world. Today, contributions are published in English and German. All articles have English summaries and legends. The journal is the official publication of several scientific radiooncological societies and publishes the relevant communications of these societies.
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