调节视网膜突触发育的细胞和分子机制

IF 5 2区 医学 Q1 NEUROSCIENCES
Whitney A. Stevens-Sostre, Mrinalini Hoon
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引用次数: 0

摘要

视网膜回路中突触的形成确保了不同类型的神经元能够有效地进行交流,以处理视觉信号。因此,突触构成了视网膜回路进行视觉计算的核心。视网膜突触多种多样,但大致可分为多伙伴带状突触和 1:1 传统突触。在这篇文章中,我们回顾了目前对调节哺乳动物视网膜突触功能建立的细胞和分子机制的理解,包括粘附蛋白、突触蛋白、细胞外基质和细胞骨架相关蛋白以及活动依赖性线索的作用。我们概述了未来的研究方向和领域,这些研究将拓展我们对这些机制的认识。了解调节突触形成和功能的调节因子不仅能揭示建立视网膜电路的综合发育过程,还能揭示疾病和退化过程中可能涉及的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular and Molecular Mechanisms Regulating Retinal Synapse Development
Synapse formation within the retinal circuit ensures that distinct neuronal types can communicate efficiently to process visual signals. Synapses thus form the core of the visual computations performed by the retinal circuit. Retinal synapses are diverse but can be broadly categorized into multipartner ribbon synapses and 1:1 conventional synapses. In this article, we review our current understanding of the cellular and molecular mechanisms that regulate the functional establishment of mammalian retinal synapses, including the role of adhesion proteins, synaptic proteins, extracellular matrix and cytoskeletal-associated proteins, and activity-dependent cues. We outline future directions and areas of research that will expand our knowledge of these mechanisms. Understanding the regulators moderating synapse formation and function not only reveals the integrated developmental processes that establish retinal circuits, but also divulges the identity of mechanisms that could be engaged during disease and degeneration.
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来源期刊
Annual Review of Vision Science
Annual Review of Vision Science Medicine-Ophthalmology
CiteScore
11.10
自引率
1.70%
发文量
19
期刊介绍: The Annual Review of Vision Science reviews progress in the visual sciences, a cross-cutting set of disciplines which intersect psychology, neuroscience, computer science, cell biology and genetics, and clinical medicine. The journal covers a broad range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, vision models, computer vision, and the mechanisms of visual disease, dysfunction, and sight restoration. The study of vision is central to progress in many areas of science, and this new journal will explore and expose the connections that link it to biology, behavior, computation, engineering, and medicine.
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