可可碱对肥胖症的治疗潜力：全面回顾。

IF 5.9 2区医学 Q1 NUTRITION & DIETETICS

Nutrition reviews Pub Date : 2024-09-13 DOI:10.1093/nutrit/nuae122

Dilem Tuğal Aslan,Zeynep Göktaş

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引用次数: 0

摘要

以慢性低度炎症为特征的肥胖症是一个重大的健康问题。人们正在探索植物中的植物化学物质的治疗用途，尤其是在防治肥胖症方面。其中，通常存在于可可和巧克力中的可可碱很有前景。虽然对可可碱的研究不如咖啡因广泛，但可可碱对人体健康有积极影响。它能改善血脂状况、辅助治疗哮喘、降低血压、调节肠道微生物群、减少肿瘤形成、调节血糖水平，还能起到保护神经的作用。研究表明，可可碱通过使白色脂肪组织变褐、激活棕色脂肪组织、抗炎和减少氧化应激等机制发挥抗肥胖作用。本研究旨在建议将可可碱作为预防肥胖相关并发症的潜在治疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Therapeutic Potential of Theobromine in Obesity: A Comprehensive Review.

Obesity, characterized by chronic low-grade inflammation, is a significant health concern. Phytochemicals found in plants are being explored for therapeutic use, particularly in combating obesity. Among these, theobromine, commonly found in cocoa and chocolate, shows promise. Although not as extensively studied as caffeine, theobromine exhibits positive effects on human health. It improves lipid profiles, aids in asthma treatment, lowers blood pressure, regulates gut microbiota, reduces tumor formation, moderates blood glucose levels, and acts as a neuroprotective agent. Studies demonstrate its anti-obesity effects through mechanisms such as browning of white adipose tissue, activation of brown adipose tissue, anti-inflammatory properties, and reduction of oxidative stress. This study aims to suggest theobromine as a potential therapeutic agent against obesity-related complications.

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来源期刊

Nutrition reviews 医学-营养学

CiteScore

12.20

自引率

1.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.