CAR T 细胞相关神经毒性：全面回顾。

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2024-11-01 DOI:10.1016/j.neurol.2024.07.005

R. Ursu , C. Belin , S. Cuzzubbo , A.F. Carpentier

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引用次数: 0

摘要

嵌合抗原受体 T 细胞（CAR T 细胞）疗法通过诱导强大的抗肿瘤反应，已成为治疗多种恶性肿瘤（尤其是血液系统恶性肿瘤）的一种前景广阔的治疗模式。然而，CAR T 细胞疗法与一系列不良事件有关，包括神经系统并发症。我们在此综述了在接受 CAR T 细胞疗法的患者中观察到的神经系统不良事件，重点关注其发生率、临床表现、潜在机制和潜在管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CAR T-cell-associated neurotoxicity: A comprehensive review

Chimeric antigen receptor T-cell (CAR T-cell) therapies have emerged as a promising treatment modality for several malignancies, particularly haematological malignancies, by inducing robust antitumour responses. However, CAR T-cell therapies are associated with a spectrum of adverse events, including neurological complications. We here provide a review of neurological adverse events observed in patients undergoing CAR T-cell therapy, focusing on their incidence, clinical manifestations, underlying mechanisms and potential management strategies.

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.