全厚软骨缺损的混合修复策略:八匹马的长期实验研究

IF 2.1 3区 医学 Q2 ORTHOPEDICS
Maria C. Fugazzola, Mylène De Ruijter, Stefanie Veraa, Saskia Plomp, Ward van Buul, Gied Hermsen, René van Weeren
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引用次数: 0

摘要

本研究的目的是评估一种用于软骨缺损病灶修复的非吸收性植入物,该植入物用于 8 匹成年马,随访期为 12 个月。这种由聚碳酸酯-尿烷-尿素生物材料组成的双层结构以三维方式打印在骨锚上,被植入八匹马股骨髌骨关节中通过手术形成的骨软骨缺损处。对死后结果的分析与同一动物对侧股骨髌骨关节股骨髌骨关节微骨折治疗缺损的结果进行了比较。12 个月后的整体宏观评分结果显示,OCI 治疗的胫骨得分高于 MF 治疗(p = 0.09),且缺损的质量和填充效果更好。组织学显示,修复组织与植入物的三维结构结合良好,邻近的原生软骨组织病理学评分显示组间无差异。核磁共振成像(MRI)和显微计算机断层扫描(Micro-CT)显示,植入组周围骨质的硬化反应总体较轻,未发现异物反应。修复组织的生物力学分析显示,植入组的峰值模量(0.74 ± 0.45)明显高于微骨折对照组(0.15 ± 0.11)(p < 0.05)。与微骨折对照组(0.06 ± 0.06)相比,动态加载对种植体组(0.23 ± 0.17)产生了更高的修复组织生长值(p < 0.05)。双层骨软骨植入物为全厚骨软骨缺损的病灶修复提供了一种安全的植入物,因为在12个月后,关节内未出现不良反应,修复部位邻近软骨的退化程度与微骨折治疗的缺损相比也无差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A hybrid repair strategy for full-thickness cartilage defects: Long-term experimental study in eight horses

A hybrid repair strategy for full-thickness cartilage defects: Long-term experimental study in eight horses

The objective of this study was to evaluate a non-resorbable implant for the focal repair of chondral defects in eight adult horses with 12-month follow-up. The bi-layered construct composed of a polycarbonate-urethane-urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted into surgically created osteochondral defects into the femoropatellar joints of eight horses. The analysis of post-mortem outcomes were compared to defects treated with microfracture in the same animal on the contralateral femoropatellar jointfemoropatellar joint. The overall macroscopic scoring after 12 months yielded higher scores in the OCI-treated stifles compared to MF treatment (p = 0.09) with better quality and filling of the defect. Histology revealed good anchorage of repair tissue growing into the 3D structure of the implant and histopathology scoring for adjacent native cartilage showed no difference between groups. MRI and micro-CT showed overall less sclerotic reactions in the surrounding bone in the implant group and no foreign body reaction was detected. Biomechanical analysis of the repair tissue revealed a significantly higher peak modulus (p < 0.05) in the implant group (0.74 ± 0.45) compared to the microfracture control group (0.15 ± 0.11). Dynamic loading yielded higher values for the repair tissue overgrowing the implant group (0.23 ± 0.17) compared to the microfracture control (0.06 ± 0.06) (p < 0.05). The bi-layered osteochondral implant provided a safe implant for focal repair of full-thickness osteochondral defects, as no adverse reaction was seen within the joints and the level of degeneration of adjacent cartilage to the repair site was not different compared to that seen in defects treated with microfracture after 12 months.

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来源期刊
Journal of Orthopaedic Research®
Journal of Orthopaedic Research® 医学-整形外科
CiteScore
6.10
自引率
3.60%
发文量
261
审稿时长
3-6 weeks
期刊介绍: The Journal of Orthopaedic Research is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.
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