蛋白激酶介导的信号通路的调控格局

IF 4 2区医学 Q2 CHEMISTRY, MEDICINAL

ACS Infectious Diseases Pub Date : 2024-09-19 DOI:10.1016/j.tplants.2024.09.003

Peng Sun, Jin-Rong Xu, Guotian Li

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引用次数: 0

摘要

水稻稻瘟病真菌 Magnaporthe oryzae 是研究真菌与植物相互作用的模型。在最近的一项磷酸化蛋白质组学研究中，Cruz-Mireles 等人以 Pmk1 通路为重点，全面分析了 M. oryzae 中与致病相关的磷酸化，整合了多种信号通路并确定了新的毒力因子。这项研究对我们了解真菌的致病机理具有广泛的意义。

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Regulatory landscape of a protein kinase-mediated signaling pathway

Rice blast fungus Magnaporthe oryzae serves as a model for studying fungal–plant interactions. In a recent phosphoproteomics study, Cruz-Mireles et al. comprehensively analyzed pathogenesis-related phosphorylation in M. oryzae with a focus on the Pmk1 pathway, integrating multiple signaling pathways and identifying new virulence factors. This study has broad implications for our understanding of fungal pathogenesis.

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来源期刊

ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES

CiteScore

9.70

自引率

3.80%

发文量

213

期刊介绍： ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.