肥大细胞：炎症和纤维化的双刃剑

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2024-09-18 DOI:10.3389/fcell.2024.1466491

Xufang Wang, Peipei Zhang, Yuxin Tang, Yanlin Chen, Enchao Zhou, Kun Gao

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引用次数: 0

摘要

作为免疫系统的重要组成部分之一，肥大细胞在过敏反应中的作用众所周知。不过，它们也参与炎症和纤维化过程。肥大细胞参与急性炎症反应的所有阶段，在先天性免疫和适应性免疫中发挥免疫调节作用。肥大细胞衍生的组胺、TNF-α和IL-6有助于炎症过程，而IL-10则介导炎症的抑制。肥大细胞与其他免疫细胞之间的相互影响也参与了炎症的发展。肥大细胞和成纤维细胞的细胞间粘附对纤维化至关重要。肥大细胞介质，包括细胞因子和蛋白酶，在纤维化过程中发挥着相互矛盾的作用。在此，我们回顾了肥大细胞在炎症和纤维化中的双刃作用。

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Mast cells: a double-edged sword in inflammation and fibrosis

As one of the key components of the immune system, mast cells are well known for their role in allergic reactions. However, they are also involved in inflammatory and fibrotic processes. Mast cells participate in all the stages of acute inflammatory responses, playing an immunomodulatory role in both innate and adaptive immunity. Mast cell-derived histamine, TNF-α, and IL-6 contribute to the inflammatory processes, while IL-10 mediates the suppression of inflammation. Crosstalk between mast cells and other immune cells is also involved in the development of inflammation. The cell–cell adhesion of mast cells and fibroblasts is crucial for fibrosis. Mast cell mediators, including cytokines and proteases, play contradictory roles in the fibrotic process. Here, we review the double-edged role of mast cells in inflammation and fibrosis.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.