频哪烷醇和酸的合成与抗真菌活性

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2024-09-16 DOI:10.1007/s10600-024-04459-4

L. L. Frolova, A. V. Popov, E. U. Ipatova, L. E. Nikitina, S. A. Lisovskaya, I. R. Gilfanov, A. V. Kutchin

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引用次数: 0

摘要

该方法包括在室温下将氧化剂加入到起始醇的溶液中，用 CrO3-AcOH 氧化顺式和反式吡喃醇，从而合成顺式和反式吡喃酸，制备收率分别为 54-58% 和 72-74%。对获得的化合物进行的抗真菌活性测试表明，季盐的活性低于起始酸，顺式异构体的功效高于反式异构体。不过，醇类本身，即顺式和反式-myrtanols 以及 (-)-myrtenol 的活性最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Antifungal Activity of Pinane Alcohols and Acids

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Synthesis and Antifungal Activity of Pinane Alcohols and Acids

A simple and efficient synthesis of cis- and trans-myrtanic acids in preparative yields of 54–58% and 72–74%, respectively, was proposed and consisted of oxidation of cis- and trans-myrtanols by CrO₃–AcOH upon addition of the oxidant to a solution of the starting alcohols at room temperature. Tests of the obtained compounds for antifungal activity showed lower activity for the quaternary salts than for the starting acids and greater efficacy for the cis-isomers than for the trans-isomers. However, the alcohols themselves, i.e., cis- and trans-myrtanols and (–)-myrtenol, had the greatest activities.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.