儿童期铅暴露与青少年睡眠问题:一项纵向队列研究

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Ying Dai, Olivia M. Halabicky, Xiaopeng Ji, Jianghong Liu
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引用次数: 0

摘要

目的 儿童时期的铅暴露与青春期较差的神经行为功能有关,但铅与青少年睡眠健康之间的关系仍不一致。本研究旨在调查青少年铅暴露与多个睡眠健康领域之间的并发和纵向关系。方法:本研究共纳入中国金坛儿童队列中的 972 名青少年进行分析。血铅水平(BLLs)分两波进行评估,年龄分别为 3-5 岁(平均 6.50 ± 2.76 μg/dL)和 11-13 岁(平均 3.12 ± 1.17 μg/dL)。11-13岁青少年的睡眠问题由家长通过儿童睡眠健康问卷(CSHQ)进行报告,由青少年通过匹兹堡睡眠质量指数(PSQI)进行自我报告。结果早期和晚期的BLL均与家长报告的睡眠问题呈正相关,包括睡眠开始延迟、夜醒、持续时间短、寄生虫病和呼吸紊乱。性别分层分析表明,经调整后,两波 BLLs 与睡眠结果(CSHQ 和 PSQI)之间的大多数关联在男性中仍具有显著的统计学意义,但这些关联的程度略有增加。只有女性青少年的第二波 BLLs 与自我报告的睡眠时间缩短之间的关联具有统计学意义。结论研究结果表明,儿童早期和晚期的铅暴露都会导致青少年出现更多的睡眠问题,而近期的铅中毒水平与家长报告的青少年睡眠健康状况不良之间的关系更为密切。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Childhood lead exposure and sleep problems in adolescents: a longitudinal cohort study

Childhood lead exposure and sleep problems in adolescents: a longitudinal cohort study

Purpose

Childhood lead exposure is linked to poorer neurobehavioral function in adolescence, but the relationship between lead and adolescent sleep health remains inconsistent. This study aimed to investigate concurrent and longitudinal associations between lead exposure and multiple sleep health domains in adolescents.

Methods

A total of 972 adolescents from China Jintan Child Cohort were included in analyses. The Blood lead levels (BLLs) were assessed in two Waves, at ages 3–5 years (mean 6.50 ± 2.76 μg/dL) and 11–13 years (mean 3.12 ± 1.17 μg/dL). Sleep problems at age 11–13 were parent-reported via the Child Sleep Health Questionnaire (CSHQ) and self-reported by adolescents using the Pittsburgh Sleep Quality Index (PSQI).

Results

Both early and later BLLs were associated positively with parental reported sleep problems, including sleep onset delay, night waking, short duration, parasomnias, and disordered breathing. Sex-stratified analyzes showed that most adjusted associations between two-Wave BLLs and sleep outcomes (CSHQ and PSQI) remained statistically significant in males, with a minor increase in the magnitude of these associations. The association between Wave II BLLs and shorter self-reported sleep duration was only statistically significant in female adolescents. Compared to children with consistently low BLLs at both ages, those with persistently high BLLs at both ages had significantly shorter parental-reported sleep duration and worse sleep onset delay.

Conclusion

Findings suggest that both early and later childhood lead exposures link to more adolescent sleep problems, with recent BLLs showing stronger associations with poor adolescent sleep health reported by their parents.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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