关于 BI 1291583 在健康日本男性受试者中的安全性和药代动力学的 I 期随机研究

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-09-19 DOI:10.1111/bcp.16249

Yusuke Tadayasu, Donald Sarubbi, Takumi Furuichi, Anastasia Eleftheraki, Shuhei Nakamura, Wiebke Sauter, Ryuzo Hanada

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引用次数: 0

摘要

支气管扩张症患者对减少炎症的治疗方案的需求尚未得到满足。Cathepsin C抑制剂有望通过减少中性粒细胞衍生的丝氨酸蛋白酶的活化来实现这一目标。在此，我们展示了一项 I 期试验的安全性和药代动力学（PK）数据，该试验评估了新型 cathepsin C 抑制剂 BI 1291583 在健康日本男性受试者中的应用情况。

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A randomized phase I study of the safety and pharmacokinetics of BI 1291583 in healthy Japanese male subjects

Bronchiectasis patients face an unmet need for treatment options that reduce inflammation. Cathepsin C inhibition is expected to achieve this by reducing the activation of neutrophil-derived serine proteases. Here, we present safety and pharmacokinetic (PK) data from a Phase I trial evaluating the novel cathepsin C inhibitor BI 1291583 in healthy Japanese male subjects.

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567