嗜酸性粒细胞增多会增加脱发症患者指甲异常的发生率和脱发的严重程度

IF 2.6 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

BioMed Research International Pub Date : 2024-09-07 DOI:10.1155/2024/5596647

Giovanni Damiani,Laura Cristina Gironi,Rosalynn R Z Conic,Massimo Del Fabbro,Paola Savoia,Marco Fiore,Wilma F Bergfeld

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引用次数: 0

摘要

背景：斑秃（AA）与嗜酸性粒细胞增多症之间的潜在联系及其在这些患者亚群中的临床表现尚不清楚。研究方法这是一项单中心回顾性观察研究，对临床和实验室数据进行了总结，并对同时患有嗜酸性粒细胞增多症的 AA 亚组进行了评估。研究结果在 205 例 AA 患者中，有 38 例（18.5%）被归类为嗜酸性粒细胞增多的 AA 患者。有趣的是，与无嗜酸性粒细胞增多症的 AA 患者相比，该组患者的近视率和指甲异常率在统计学上更高（P < 0.05）。与无嗜酸性粒细胞增多症的年龄和性别匹配的 AA 患者相比，有嗜酸性粒细胞增多症的 AA 患者出现更严重脱发的几率要高出 3.70 倍。结论：嗜酸性粒细胞增多症 AA 患者具有独特的临床和实验室特征，因此未来的研究可能会探讨 IL-5 抑制剂的使用。

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Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata.

Background: The potential link between alopecia areata (AA) and eosinophilia is unclear, as well as its clinical manifestations in these patients' subsets. Methods: This is a monocentric retrospective observational study in which clinical and laboratory data were summarized and evaluated the AA subset with concurrent eosinophilia. Results: In a sample of 205 AA patients, 38 (18.5%) were classified as AA with eosinophilia. Interestingly, this subset of patients had a statistically higher prevalence of atopia and nail abnormalities (p < 0.05) than AA without eosinophilia. AA patients with eosinophilia had a 3.70 higher odds of more severe hair loss versus age- and gender-matched AA without eosinophilia. Conclusions: AA patients with eosinophilia had distinctive clinical and laboratory characteristics, so future studies may potentially explore the use of IL-5 inhibitors.

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来源期刊

BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.70

自引率

0.00%

发文量

1942

审稿时长

19 weeks

期刊介绍： BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.