{"title":"评论\"神经眼科中的带状疱疹:实用方法","authors":"Duncan Marston, Sara Xuereb","doi":"10.1038/s41433-024-03350-4","DOIUrl":null,"url":null,"abstract":"<p>We have read with great interest the recent article by Tao et al. [1] which provides the reader with a concise overview regarding the neuro-ophthalmic manifestations of herpes zoster and their management. However, we would like to make a comment regarding what in our opinion is a clinical misinterpretation of Hutchinson’s sign as a predictor of neuro-ophthalmic disease.</p><p>In 1866, Sir Jonathan Hutchinson documented “My cases <i>[n</i> = <i>13]</i> are as yet too few in number to authorize a confident statement, but thus far I have never seen the whole side of the nose affected without also witnessing inflammation of the eye and I have never seen the eye inflame unless the side of the nose showed vesicles.” [2]. A prospective study carried out by Adam et al. [3] did not find any statistical significance between Hutchinson’s sign (nasociliary nerve involvement) and herpes zoster ophthalmicus (p = 0.184). However, statistical significance was approached when Hutchinson’s sign coexisted with blepharitis and conjunctivitis (p = 0.067). Furthermore, supratrocheal nerve involvement showed greater statistical significance (pvalue = 0.0004) for the development of herpes zoster ophthalmicus, whilst having a positive predictive value of 0.6 and a negative predictive value of 0.89 for associated eye involvement [3].</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comment on: “Herpes Zoster in neuro-ophthalmology: a practical approach”\",\"authors\":\"Duncan Marston, Sara Xuereb\",\"doi\":\"10.1038/s41433-024-03350-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We have read with great interest the recent article by Tao et al. [1] which provides the reader with a concise overview regarding the neuro-ophthalmic manifestations of herpes zoster and their management. However, we would like to make a comment regarding what in our opinion is a clinical misinterpretation of Hutchinson’s sign as a predictor of neuro-ophthalmic disease.</p><p>In 1866, Sir Jonathan Hutchinson documented “My cases <i>[n</i> = <i>13]</i> are as yet too few in number to authorize a confident statement, but thus far I have never seen the whole side of the nose affected without also witnessing inflammation of the eye and I have never seen the eye inflame unless the side of the nose showed vesicles.” [2]. A prospective study carried out by Adam et al. [3] did not find any statistical significance between Hutchinson’s sign (nasociliary nerve involvement) and herpes zoster ophthalmicus (p = 0.184). However, statistical significance was approached when Hutchinson’s sign coexisted with blepharitis and conjunctivitis (p = 0.067). Furthermore, supratrocheal nerve involvement showed greater statistical significance (pvalue = 0.0004) for the development of herpes zoster ophthalmicus, whilst having a positive predictive value of 0.6 and a negative predictive value of 0.89 for associated eye involvement [3].</p>\",\"PeriodicalId\":12125,\"journal\":{\"name\":\"Eye\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eye\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41433-024-03350-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41433-024-03350-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Comment on: “Herpes Zoster in neuro-ophthalmology: a practical approach”
We have read with great interest the recent article by Tao et al. [1] which provides the reader with a concise overview regarding the neuro-ophthalmic manifestations of herpes zoster and their management. However, we would like to make a comment regarding what in our opinion is a clinical misinterpretation of Hutchinson’s sign as a predictor of neuro-ophthalmic disease.
In 1866, Sir Jonathan Hutchinson documented “My cases [n = 13] are as yet too few in number to authorize a confident statement, but thus far I have never seen the whole side of the nose affected without also witnessing inflammation of the eye and I have never seen the eye inflame unless the side of the nose showed vesicles.” [2]. A prospective study carried out by Adam et al. [3] did not find any statistical significance between Hutchinson’s sign (nasociliary nerve involvement) and herpes zoster ophthalmicus (p = 0.184). However, statistical significance was approached when Hutchinson’s sign coexisted with blepharitis and conjunctivitis (p = 0.067). Furthermore, supratrocheal nerve involvement showed greater statistical significance (pvalue = 0.0004) for the development of herpes zoster ophthalmicus, whilst having a positive predictive value of 0.6 and a negative predictive value of 0.89 for associated eye involvement [3].
期刊介绍:
Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists.
Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.