Shailykumari K. Patel, Aniket A. Deshmukh, Lata Kahar, Pallepogu Raghavaiah and Vinay K. Singh
{"title":"手性金属-二硫代氨基甲酸盐络合物--含有酚类基团:合成、晶体学、光物理和微观研究","authors":"Shailykumari K. Patel, Aniket A. Deshmukh, Lata Kahar, Pallepogu Raghavaiah and Vinay K. Singh","doi":"10.1039/D4NJ03057E","DOIUrl":null,"url":null,"abstract":"<p >We report a novel series of chiral monometallic dithiocarbamate complexes with pendant phenolic groups, formulated as [M{κ<small><sub>2</sub></small>S^S-S<small><sub>2</sub></small>CN(CH<small><sub>2</sub></small>PhOH)(CH(<em>S</em>-CH<small><sub>3</sub></small>))(NaPh)}<small><sub>2</sub></small>] (M = Ni(<small>II</small>) <em>S</em>,<em>S</em>-<strong>1</strong>, Cu(<small>II</small>) <em>S</em>,<em>S</em>-<strong>2</strong>, Zn(<small>II</small>) <em>S</em>,<em>S</em>-<strong>3</strong>) and [M{κ<small><sub>2</sub></small>S^S-S<small><sub>2</sub></small>CN(CH<small><sub>2</sub></small>PhOH)(CH(<em>R</em>-CH<small><sub>3</sub></small>))(NaPh)}<small><sub>2</sub></small>] (M = Ni(<small>II</small>) <em>R</em>,<em>R</em>-<strong>4</strong>, Cu(<small>II</small>) <em>R</em>,<em>R</em>-<strong>5</strong>, Zn(<small>II</small>) <em>R</em>,<em>R</em>-<strong>6</strong>). These compounds were synthesized through a process involving chiral amino precursors <em>S</em>-HL<small><sup>1</sup></small>, <em>R</em>-HL<small><sup>2</sup></small>, CS<small><sub>2</sub></small> and the corresponding metal acetates. All the compounds have been characterized by microanalysis and standard spectroscopic methods such as <small><sup>1</sup></small>H and <small><sup>13</sup></small>C{<small><sup>1</sup></small>H}NMR, IR, UV-visible absorption and EPR spectroscopy. The spectral data suggest a square planar coordination geometry around the nickel(<small>II</small>) and copper(<small>II</small>) centers and a tetrahedral coordination geometry around zinc(<small>II</small>), which is corroborated by density functional theory calculations. The unprecedented molecular structures of imine precursors <em>S</em>-I, <em>R</em>-I and Ni(<small>II</small>)-dithiocarbamate complex <em>S</em>,<em>S</em>-<strong>1</strong> were elucidated by single crystal X-ray diffraction (SCXRD), and their crystal packing patterns were studied. Evidently, the change in chirality could not induce changes in the donor–acceptor sites of <em>S</em>-I and <em>R</em>-I, and their molecules are primarily stabilized by O–H⋯N and C–H⋯π interactions, forming a 2D sheet-like structure in the <em>ab</em>-plane. Notably, the chiral <em>S</em>,<em>S</em>-<strong>1</strong> complex crystallized in a monomeric achiral space group (triclinic, P1) in which two dithiocarbamate ligands are bonded to the nickel(<small>II</small>) ion in a S^S chelating mode forming a square planar geometry around the metal center. The photophysical properties of all the compounds have been investigated using UV-visible absorption, emission, and thermogravimetric analyses. Compounds exhibited intense blue photoluminescence with maximum emissions in the 330–336 nm region upon excitation in the UV region. A molecular docking study was performed to validate the potentials of these compounds in protein–ligand interactions against B-DNA Dodecamer (PDB Id: 1BNA) and cyclins (PDB Id: 1w98), which are indeed essential proteins of the cell cycle, and their proper functioning is necessary for the human health.</p>","PeriodicalId":95,"journal":{"name":"New Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chiral metal–dithiocarbamate complexes with pendant phenolic groups: synthesis, crystallographic, photophysical and in silico study†\",\"authors\":\"Shailykumari K. Patel, Aniket A. Deshmukh, Lata Kahar, Pallepogu Raghavaiah and Vinay K. Singh\",\"doi\":\"10.1039/D4NJ03057E\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >We report a novel series of chiral monometallic dithiocarbamate complexes with pendant phenolic groups, formulated as [M{κ<small><sub>2</sub></small>S^S-S<small><sub>2</sub></small>CN(CH<small><sub>2</sub></small>PhOH)(CH(<em>S</em>-CH<small><sub>3</sub></small>))(NaPh)}<small><sub>2</sub></small>] (M = Ni(<small>II</small>) <em>S</em>,<em>S</em>-<strong>1</strong>, Cu(<small>II</small>) <em>S</em>,<em>S</em>-<strong>2</strong>, Zn(<small>II</small>) <em>S</em>,<em>S</em>-<strong>3</strong>) and [M{κ<small><sub>2</sub></small>S^S-S<small><sub>2</sub></small>CN(CH<small><sub>2</sub></small>PhOH)(CH(<em>R</em>-CH<small><sub>3</sub></small>))(NaPh)}<small><sub>2</sub></small>] (M = Ni(<small>II</small>) <em>R</em>,<em>R</em>-<strong>4</strong>, Cu(<small>II</small>) <em>R</em>,<em>R</em>-<strong>5</strong>, Zn(<small>II</small>) <em>R</em>,<em>R</em>-<strong>6</strong>). These compounds were synthesized through a process involving chiral amino precursors <em>S</em>-HL<small><sup>1</sup></small>, <em>R</em>-HL<small><sup>2</sup></small>, CS<small><sub>2</sub></small> and the corresponding metal acetates. All the compounds have been characterized by microanalysis and standard spectroscopic methods such as <small><sup>1</sup></small>H and <small><sup>13</sup></small>C{<small><sup>1</sup></small>H}NMR, IR, UV-visible absorption and EPR spectroscopy. The spectral data suggest a square planar coordination geometry around the nickel(<small>II</small>) and copper(<small>II</small>) centers and a tetrahedral coordination geometry around zinc(<small>II</small>), which is corroborated by density functional theory calculations. The unprecedented molecular structures of imine precursors <em>S</em>-I, <em>R</em>-I and Ni(<small>II</small>)-dithiocarbamate complex <em>S</em>,<em>S</em>-<strong>1</strong> were elucidated by single crystal X-ray diffraction (SCXRD), and their crystal packing patterns were studied. Evidently, the change in chirality could not induce changes in the donor–acceptor sites of <em>S</em>-I and <em>R</em>-I, and their molecules are primarily stabilized by O–H⋯N and C–H⋯π interactions, forming a 2D sheet-like structure in the <em>ab</em>-plane. Notably, the chiral <em>S</em>,<em>S</em>-<strong>1</strong> complex crystallized in a monomeric achiral space group (triclinic, P1) in which two dithiocarbamate ligands are bonded to the nickel(<small>II</small>) ion in a S^S chelating mode forming a square planar geometry around the metal center. The photophysical properties of all the compounds have been investigated using UV-visible absorption, emission, and thermogravimetric analyses. Compounds exhibited intense blue photoluminescence with maximum emissions in the 330–336 nm region upon excitation in the UV region. A molecular docking study was performed to validate the potentials of these compounds in protein–ligand interactions against B-DNA Dodecamer (PDB Id: 1BNA) and cyclins (PDB Id: 1w98), which are indeed essential proteins of the cell cycle, and their proper functioning is necessary for the human health.</p>\",\"PeriodicalId\":95,\"journal\":{\"name\":\"New Journal of Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/nj/d4nj03057e\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/nj/d4nj03057e","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Chiral metal–dithiocarbamate complexes with pendant phenolic groups: synthesis, crystallographic, photophysical and in silico study†
We report a novel series of chiral monometallic dithiocarbamate complexes with pendant phenolic groups, formulated as [M{κ2S^S-S2CN(CH2PhOH)(CH(S-CH3))(NaPh)}2] (M = Ni(II) S,S-1, Cu(II) S,S-2, Zn(II) S,S-3) and [M{κ2S^S-S2CN(CH2PhOH)(CH(R-CH3))(NaPh)}2] (M = Ni(II) R,R-4, Cu(II) R,R-5, Zn(II) R,R-6). These compounds were synthesized through a process involving chiral amino precursors S-HL1, R-HL2, CS2 and the corresponding metal acetates. All the compounds have been characterized by microanalysis and standard spectroscopic methods such as 1H and 13C{1H}NMR, IR, UV-visible absorption and EPR spectroscopy. The spectral data suggest a square planar coordination geometry around the nickel(II) and copper(II) centers and a tetrahedral coordination geometry around zinc(II), which is corroborated by density functional theory calculations. The unprecedented molecular structures of imine precursors S-I, R-I and Ni(II)-dithiocarbamate complex S,S-1 were elucidated by single crystal X-ray diffraction (SCXRD), and their crystal packing patterns were studied. Evidently, the change in chirality could not induce changes in the donor–acceptor sites of S-I and R-I, and their molecules are primarily stabilized by O–H⋯N and C–H⋯π interactions, forming a 2D sheet-like structure in the ab-plane. Notably, the chiral S,S-1 complex crystallized in a monomeric achiral space group (triclinic, P1) in which two dithiocarbamate ligands are bonded to the nickel(II) ion in a S^S chelating mode forming a square planar geometry around the metal center. The photophysical properties of all the compounds have been investigated using UV-visible absorption, emission, and thermogravimetric analyses. Compounds exhibited intense blue photoluminescence with maximum emissions in the 330–336 nm region upon excitation in the UV region. A molecular docking study was performed to validate the potentials of these compounds in protein–ligand interactions against B-DNA Dodecamer (PDB Id: 1BNA) and cyclins (PDB Id: 1w98), which are indeed essential proteins of the cell cycle, and their proper functioning is necessary for the human health.