Fuyuan Tan, Wenliang Li, Long Qiu, Jie Lyu, Haiyue Peng, Wenbing Ding, Jiali Liao, Yuanyou Yang, Ning Liu, Feize Li
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89Zr PET imaging guided validation of the medicinal potentiality of UiO-66 based nano drug delivery system
In this work, positron nuclide 89Zr was introduced to verify the medical feasibility of UiO-66 as a medical nanodrug carrier via positron emission tomography-computed tomography (PET–CT) imaging. A radiopharmaceutical nanodrug, DOX@89Zr-UiO-66-PEG-FA, was well constructed through subsequent doxorubicin (DOX) encapsulation and surface PEGylation of UiO-66 nanocarrier radiolabeled with 89Zr. Subsequently, tumoricidal effect of DOX@89Zr-UiO-66-PEG-FA in murine breast cancer (4T1) models had been evaluated. DOX@89Zr-UiO-66-PEG-FA has acceptable stability, excellent cargo loading rate (79.28%), pH-stimulated response property and high cancer cell binding affinity. As a result, PET–CT guided anticancer investigations reveal that DOX@89Zr-UiO-66-PEG-FA can well suppress tumor growth with satisfactory biosafety.
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An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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