制备用于高效气相色谱分离位置异构体的烷基微孔有机网络毛细管柱

IF 3 3区 生物学 Q2 BIOCHEMICAL RESEARCH METHODS
Zhi-Yong Gao, Xi-Jin Li, Yuan-Yuan Cui, Cheng-Xiong Yang
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引用次数: 0

摘要

微孔有机网络(MON)具有表面积大、热稳定性好和易于改性等特点,是气相色谱仪(GC)领域的理想候选材料。由于微孔有机物的种类有限且网络高度共轭,其应用仍处于起步阶段并受到限制。为了加快其发展并丰富其在气相色谱中的应用,我们在此报告了合成烷基 MON 及其毛细管柱用于气相色谱分离位置异构体的首个实例。我们采用线性 1,8-二溴辛烷作为烷基单体,而不是传统的芳香族单体来构建新型烷基 MON,以减少 MON 固有的共轭特性。这种烷基 MON 具有良好的热稳定性(高达 350°C)、较大的比表面积(1173 m2 g-1)和非极性特点,可以很好地分辨烷烃、烷基苯、醇、酮和不同位置的异构体,包括二氯苯、三氯苯、溴甲苯、硝基甲苯、甲基苯甲醛和离子酮,其检出限(0.003 mg mL-1)和定量限(0.10 mg mL-1)分别为 0.003 mg mL-1 和 0.10 mg mL-1。原位生长制备的烷基 MON 色谱柱在保留相对标准偏差(RSDs%,日内,n = 7)、0.06%-0.53%(日内,n = 7)和 2.87%-10.59%(柱间,n = 3)方面表现出卓越的持续时间和精确度。此外,在分辨甲基苯甲醛、溴甲苯和氯甲苯异构体方面,制造的烷基 MON 涂层毛细管柱比三种商用气相色谱柱具有更好的分辨能力。这项工作揭示了合成烷基 MON 的可行性,并展示了其在位置异构体分离方面的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation of alkyl microporous organic network-based capillary column for an efficient gas chromatographic separation of position isomers

The large surface area, excellent thermal stability and easy modification make microporous organic networks (MONs) good candidates in the field of gas chromatography (GC). Due to the limited species and highly conjugated networks of MONs, their applications are still in infancy and restricted. To accelerate their developments and to enrich their types in GC, here we report the first example of synthesizing alkyl MON and its capillary column for GC separation of position isomers. Linear 1,8-dibromooctane is used as the alkyl monomer instead of traditional aromatic ones to construct novel alkyl MON to decrease the inherent conjugated characteristic of MONs. The alkyl MON exhibits good thermal stability (up to 350°C), large surface area (1173 m2 g−1), and non-polar character, allowing good resolution for alkanes, alkyl benzenes, alcohols, ketones, and diverse position isomers, including dichlorobenzene, trichlorobenzene, bromotoluene, nitrotoluene, methylbenzaldehyde, and ionone with the limits of detection (0.003 mg mL−1) and limits of quantitation of (0.10 mg mL−1). The in situ growth–prepared alkyl MON column demonstrates remarkable duration time and precisions for the retention relative standard deviations, (RSDs%, intra-day, n = 7), 0.06%–0.53% (intra-day, n = 7), and 2.87%–10.59% (column-to-column, n = 3). In addition, the fabricated alkyl MON-coated capillary column offers better resolution than three commercial GC columns for the resolution of methylbenzaldehyde, bromotoluene, and chlorotoluene isomers. This work reveals the practicability for synthesizing alkyl MONs and demonstrates their prospects for position isomers separation.

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来源期刊
ELECTROPHORESIS
ELECTROPHORESIS 生物-分析化学
CiteScore
6.30
自引率
13.80%
发文量
244
审稿时长
1.9 months
期刊介绍: ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.
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