迷你猪和人类皮肤组织的流变学和脂质特征:不同位置和深度的比较研究

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Harsa Mitra, Evelyn Nonamaker, Ria D. Corder, Luis Solorio, Arezoo M. Ardekani
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引用次数: 0

摘要

了解小鼠和人体皮肤的流变学对于改进给药方法,尤其是注射给药方法至关重要。尽管对皮肤(尤其是皮下层)的粘弹性进行了许多研究,但不同临床部位的比较分析以及有关水合作用或脂质水平影响的数据却很少。本研究采用剪切流变学和脂质分析方法,对尤卡坦小型猪的乳房、腹部和颈部三个解剖部位以及三个不同深度层的粘弹性和脂质含量进行评估。研究报告介绍了粘弹性如何随频率、时间和应变而变化,并注意到高应变幅度下的应变硬化和剪切变薄。研究还将人类男性和女性腹部组织与小猪组织进行了比较,突出了不同的粘弹性特征以及脂质在其中的作用。研究结果表明,存在基于物种、解剖位置、组织深度和性别的流变学差异。此外,还讨论了使用雄性迷你猪模型研究人类雄性皮下组织的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Rheological and Lipid Characterization of Minipig and Human Skin Tissue: A Comparative Study Across Different Locations and Depths

Rheological and Lipid Characterization of Minipig and Human Skin Tissue: A Comparative Study Across Different Locations and Depths

Understanding the rheology of minipig and human skin is crucial for enhancing drug delivery methods, particularly for injections. Despite many studies on skin’s viscoelasticity, especially the subcutaneous layer, comparative analyses across different clinical sites are scarce, as is data on the impact of hydration or lipid levels. This study employs shear rheology and lipid analysis to evaluate viscoelasticity and lipid content across three anatomical locations—breast, belly, and neck and three different depth layers in Yucatan minipigs. It reports on how viscoelastic properties change with frequency, time, and strain, noting strain-stiffening and shear-thinning at high strain amplitudes. Human male and female abdominal tissues are also compared to minipig tissues, highlighting distinct viscoelastic traits and lipid’s role in them. The findings suggest the existence of species, anatomical location, tissue depth, and sex-based rheological differences. Furthermore, the use of male minipig models for studying human male subcutaneous tissue is discussed.

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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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