治疗新生儿糖尿病婴儿的胰岛素输送技术:系统综述

IF 3.8 3区 医学 Q2 Medicine
Raffaella Panza, Valentina Cattivera, Jacopo Colella, Maria Elisabetta Baldassarre, Manuela Capozza, Luca Zagaroli, Maria Laura Iezzi, Nicola Laforgia, Maurizio Delvecchio
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引用次数: 0

摘要

新生儿糖尿病是一种罕见的糖代谢紊乱疾病,在出生后 6 个月内发病。最初的治疗以输注胰岛素为主。尽管目前还缺乏相关指南,但糖尿病治疗技术还是非常有用的。本研究旨在全面回顾有关胰岛素治疗糖尿病技术的安全性和有效性的文献,为临床医生管理新生儿糖尿病婴儿提供支持。研究共收录了 22 篇文献,其中大部分为病例报告或系列病例。近二十年前,第一批使用胰岛素泵治疗新生儿糖尿病的婴儿就已问世。多年来,在治疗这些患者时增加了连续血糖监测系统,以便更好地定制胰岛素用量。在某些情况下,胰岛素被稀释以进一步减少剂量。糖尿病技术的改进促使临床医生也开始使用新的设备和算法为患有新生儿糖尿病的婴儿注射胰岛素。这些系统既安全又有效,可缩短住院时间,还能帮助临床医生在一过性糖尿病缓解期断胰岛素,或根据分子诊断建议从胰岛素转为磺脲类药物。新生儿糖尿病婴儿胰岛素给药新技术可以安全使用,闭环算法可以在这些情况下正常工作,优化血糖控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insulin Delivery Technology for Treatment of Infants with Neonatal Diabetes Mellitus: A Systematic Review

Insulin Delivery Technology for Treatment of Infants with Neonatal Diabetes Mellitus: A Systematic Review

Neonatal diabetes mellitus is a rare disorder of glucose metabolism with onset within the first 6 months of life. The initial treatment is based on insulin infusion. The technologies for diabetes treatment can be very helpful, even if guidelines are still lacking. The current study aimed to provide a comprehensive review of the literature about the safety and efficacy of insulin treatment with technology for diabetes to support clinicians in the management of infants with neonatal diabetes mellitus. A total of 22 papers were included, most of them case reports or case series. The first infants with neonatal diabetes mellitus treated with insulin pumps were described nearly two decades ago. Over the years, continuous glucose monitoring systems were added to treat these individuals, allowing for a better customization of insulin administration. Insulin was diluted in some cases to further minimize the doses. Improvement in technology for diabetes prompted clinicians to use new devices and algorithms for insulin delivery in infants with neonatal diabetes as well. These systems are safe and effective, may shorten hospital stay, and help clinicians weaning insulin during the remission phase in the transient forms or switching from insulin to sulfonylurea when suggested by the molecular diagnosis. New technologies for insulin delivery in infants with neonatal diabetes can be used safely and closed-loop algorithms can work properly in these situations, optimizing blood glucose control.

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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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