通过脑立体定向注射对胶质瘤干细胞进行光热治疗的新型 NIR-II 3,5-Julolidinyl aza-BODIPY

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-09-20 DOI:10.1021/acsmaterialslett.4c01447

Lulu Cao, Zhiqiang Cui, Dongxiang Zhang, Yikun Li, Xiaoyan Gao, Rong Shang, Xin-Dong Jiang, Jianjun Du, Xiaohong Sun

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引用次数: 0

摘要

在第二个近红外窗口（NIR-II）具有吸收功能的功能性染料在光热疗法中大有可为。本文制备了新型 NIR-II 3,5-julolidinyl aza-BODIPY (JLD)，并首次通过 X 射线晶体分析进行了确认。其分子堆积结构有利于 J 聚集堆积模式。自组装的JLD-纳米粒子（JLD-NPs）发出荧光（λem = 962 nm, Φf = 0.1%），峰带覆盖900-1300 nm的近红外-II波段。光热转换效率很高，经计算为 79%。JLD-NPs 在近红外-II波段915 nm激光照射下具有良好的肿瘤抑制能力，通过脑立体定向注射促进胶质母细胞瘤细胞凋亡和抑制干细胞，影响迁移和侵袭等恶性事件的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection

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Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection

Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY (JLD) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J-aggregation packing mode. Self-assembled JLD-nanoparticles (JLD-NPs) emit fluorescence (λ_em = 962 nm, Φ_f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD-NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.