用于微型设备的刺激响应型水凝胶光基三维打印:最新进展与展望

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Chen Xin, Neng Xia, Li Zhang
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引用次数: 0

摘要

由具有高度环境适应性的刺激响应性水凝胶组成的微型装置目前被认为是生物医学、精密传感器和可调光学领域具有竞争力的候选产品。可靠而先进的制造方法对于最大限度地提高微型设备的应用能力至关重要。光基三维(3D)打印技术具有适用材料广、加工精度高、三维制造能力强等优点,适合开发具有各种功能的微型器件。本文总结并重点介绍了光基三维打印微型器件的最新进展,重点介绍了光基制造技术、智能刺激响应水凝胶和可调谐微型器件在微型货物操纵、靶向药物和细胞递送、活性支架、环境传感和光学成像等领域的最新突破。最后,介绍了可调微型装置从实验室向实际工程应用过渡所面临的挑战。此外,还阐述了未来促进可调谐微型装置发展的机遇,这将有助于提高人们对这些微型装置的认识,并进一步实现它们在各个领域的实际应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Light-based 3D printing of stimulus-responsive hydrogels for miniature devices: recent progress and perspective

Light-based 3D printing of stimulus-responsive hydrogels for miniature devices: recent progress and perspective

Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine, precise sensors, and tunable optics. Reliable and advanced fabrication methods are critical for maximizing the application capabilities of miniature devices. Light-based three-dimensional (3D) printing technology offers the advantages of a wide range of applicable materials, high processing accuracy, and strong 3D fabrication capability, which is suitable for the development of miniature devices with various functions. This paper summarizes and highlights the recent advances in light-based 3D-printed miniaturized devices, with a focus on the latest breakthroughs in light-based fabrication technologies, smart stimulus-responsive hydrogels, and tunable miniature devices for the fields of miniature cargo manipulation, targeted drug and cell delivery, active scaffolds, environmental sensing, and optical imaging. Finally, the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are presented. Future opportunities that will promote the development of tunable microdevices are elaborated, contributing to their improved understanding of these miniature devices and further realizing their practical applications in various fields.

Graphic abstract

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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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