藻酸钠敷料在糖尿病伤口愈合中靶向给药的最新进展

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-08-27 DOI:10.1039/d4tb01049c

Mohammad Ebrahim Astaneh, Alireza Hashemzadeh, Narges Fereydouni

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引用次数: 0

摘要

糖尿病伤口由于愈合受损和并发症风险增加，给医疗保健带来了巨大挑战。近年来，为解决这些问题，人们开发了各种具有刺激响应特性的给药系统。这些系统可实现精确的剂量控制和定制的药物释放，促进组织的全面修复和再生。本综述探讨了用于糖尿病伤口愈合的靶向治疗药物，如羧甲基壳聚糖-精氨酸水凝胶制剂、纳米纤维垫和核壳纳米结构。此外，纳米技术与多功能仿生支架的结合也有望提高伤口愈合效果。未来的研究应侧重于优化三维生物打印伤口敷料的设计、材料和打印参数，以及探索同时释放抗生素和一氧化氮以改善伤口愈合的组合策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

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Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Diabetic wounds pose a significant challenge in healthcare due to impaired healing and increased risk of complications. In recent years, various drug delivery systems with stimuli-responsive features have been developed to address these issues. These systems enable precise dosage control and tailored drug release, promoting comprehensive tissue repair and regeneration. This review explores targeted therapeutic agents, such as carboxymethyl chitosan–alginate hydrogel formulations, nanofiber mats, and core–shell nanostructures, for diabetic wound healing. Additionally, the integration of nanotechnology and multifunctional biomimetic scaffolds shows promise in enhancing wound healing outcomes. Future research should focus on optimizing the design, materials, and printing parameters of 3D-bio-printed wound dressings, as well as exploring combined strategies involving the simultaneous release of antibiotics and nitric oxide for improved wound healing.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices