鲸目动物胰腺核糖核酸酶基因(RNase1)的适应性进化

IF 3.5 1区 生物学 Q1 ZOOLOGY
Datian LANG, Junsong ZHAO, Songju LIU, Yuan MU, Tiantian ZOU
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引用次数: 0

摘要

胰腺核糖核酸酶(RNase1)是一种由胰腺产生的消化酶,与饮食习惯的功能适应有关,被认为是研究分子进化的一个有吸引力的模型系统。在这项研究中,我们鉴定了来自 114 个物种的 218 个功能基因和 48 个假基因,它们跨越了所有四个 Cetartiodactyla 系:两个草食系(Ruminantia 和 Tylopoda)和两个非草食系(Cetancodonta 和 Suoidea)。在两个食草动物系的所有物种中都检测到了多个 RNase1 基因,系统发育和基因组位置分析表明,Ruminantia 和 Tylopoda 中发生了独立的基因复制事件。在 Ruminantia 中,基因复制事件发生在中始新世的祖先分支中,当时气候季节性增强,Ruminantia 在此期间迅速辐射。与此相反,在两个非食草动物系(Cetancodonta 和 Suoidea)的物种中只观察到一个 RNase1 基因,这表明之前的鲸目动物特异性丢失假说应被否定。此外,两个食草动物系(反刍兽类和泰罗兽类)中重复的 RNase1 基因可能已经发生了功能分化。结合基因复制与中始新世气候季节性增强之间的时间巧合,这种功能分化表明 RNase1 基因复制有利于反刍动物利用数量有限的稀疏纤维植被并适应气候的季节性变化。总之,研究结果表明,RNase1基因在反刍兽科(Cetartiodactyla)中具有复杂而有趣的进化模式,并展示了生物适应环境的分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adaptive evolution of pancreatic ribonuclease gene (RNase1) in Cetartiodactyla
Pancreatic ribonuclease (RNase1), a digestive enzyme produced by the pancreas, is associated with the functional adaptation of dietary habits and is regarded as an attractive model system for studies of molecular evolution. In this study, we identified 218 functional genes and 48 pseudogenes from 114 species that span all four Cetartiodactyla lineages: two herbivorous lineages (Ruminantia and Tylopoda) and two non‐herbivorous lineages (Cetancodonta and Suoidea). Multiple RNase1 genes were detected in all species of the two herbivorous lineages, and phylogenetic and genomic location analyses demonstrated that independent gene duplication events occurred in Ruminantia and Tylopoda. In Ruminantia, the gene duplication events occurred in the ancestral branches of the lineage in the Middle Eocene, a time of increasing climatic seasonality during which Ruminantia rapidly radiated. In contrast, only a single RNase1 gene was observed in the species of the two non‐herbivorous lineages (Cetancodonta and Suoidea), suggesting that the previous Cetacea‐specific loss hypothesis should be rejected. Moreover, the duplicated genes of RNase1 in the two herbivorous lineages (Ruminantia and Tylopoda) may have undergone functional divergence. In combination with the temporal coincidence between gene replication and the enhanced climatic seasonality during the Middle Eocene, this functional divergence suggests that RNase1 gene duplication was beneficial for Ruminantia to use the limited quantities of sparse fibrous vegetation and adapt to seasonal changes in climate. In summary, the findings indicate a complex and intriguing evolutionary pattern of RNase1 in Cetartiodactyla and demonstrate the molecular mechanisms by which organisms adapt to the environment.
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来源期刊
CiteScore
6.40
自引率
12.10%
发文量
81
审稿时长
>12 weeks
期刊介绍: The official journal of the International Society of Zoological Sciences focuses on zoology as an integrative discipline encompassing all aspects of animal life. It presents a broader perspective of many levels of zoological inquiry, both spatial and temporal, and encourages cooperation between zoology and other disciplines including, but not limited to, physics, computer science, social science, ethics, teaching, paleontology, molecular biology, physiology, behavior, ecology and the built environment. It also looks at the animal-human interaction through exploring animal-plant interactions, microbe/pathogen effects and global changes on the environment and human society. Integrative topics of greatest interest to INZ include: (1) Animals & climate change (2) Animals & pollution (3) Animals & infectious diseases (4) Animals & biological invasions (5) Animal-plant interactions (6) Zoogeography & paleontology (7) Neurons, genes & behavior (8) Molecular ecology & evolution (9) Physiological adaptations
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